CAJ | 학술논문

目的：研究单纯疱疹病毒性角膜炎角膜组织病毒潜伏感染的临床诊断及治疗的过程，为临床合理诊治提供依据。方法选取2010年3月－2013年10月进行治疗的98例单纯疱疹病毒性角膜炎患者为研究对象，所有患者随机分为两组，各49例，试验组患者采用PCR检查与综合疗法治疗，对照组患者采用常规免疫荧光检查与治疗；观察两组患者角膜组织病毒潜伏感染的临床诊断和治疗效果，并采用SPSS 15．0软件进行统计分析。结果对照组患者免疫荧光检测后阳性检出率83．7％，试验组患者PCR检测后阳性检出率95．9％，试验组的阳性检出率明显高于对照组；患者治疗后总有效率对照组85．7％，试验组患者为98．0％，试验组的总有效率明显高于对照组，差异有统计学意义（P＜0．05）。结论 PCR检查以及综合疗法对临床诊断和治疗单纯疱疹病毒性角膜炎角膜组织病毒潜伏感染灵敏度高、疗效确切，有利于患者的康复。
목적：연구단순포진병독성각막염각막조직병독잠복감염적림상진단급치료적과정，위림상합리진치제공의거。방법선취2010년3월－2013년10월진행치료적98례단순포진병독성각막염환자위연구대상，소유환자수궤분위량조，각49례，시험조환자채용PCR검사여종합요법치료，대조조환자채용상규면역형광검사여치료；관찰량조환자각막조직병독잠복감염적림상진단화치료효과，병채용SPSS 15．0연건진행통계분석。결과대조조환자면역형광검측후양성검출솔83．7％，시험조환자PCR검측후양성검출솔95．9％，시험조적양성검출솔명현고우대조조；환자치료후총유효솔대조조85．7％，시험조환자위98．0％，시험조적총유효솔명현고우대조조，차이유통계학의의（P＜0．05）。결론 PCR검사이급종합요법대림상진단화치료단순포진병독성각막염각막조직병독잠복감염령민도고、료효학절，유리우환자적강복。
OBJECTIVE To study the process of clinical diagnosis and treatment of herpes simplex virus keratitis with corneal tissue infected by virus latently ,so as to provide a reasonable basis for clinical diagnosis and treat‐ment .METHODS Totally 98 cases of patients with herpes simplex virus keratitis who were treated in the hospital from Mar .2010 to Oct .2013 were chosen as study objects .All patients were randomly divided into two groups with 49 cases each .The experiment group adopted PCR examination and combination therapy for treatment while the control group was just treated with conventional immunofluorescence examination .The clinical diagnosis and curative effect of the two groups were observed and the results were analyzed by SPSS 15 .0 software .RESULTS The positive virus detection rate in the control group was 83 .7% through immunofluorescence ;while the positive virus detection rate of the experimental group was 95 .9% through PCR test ;the positive detection rate was signif‐icantly higher in the experimental group (P< 0 .05) .The total curative effective rate in the control group was 85 .7% ,which was significantly lower than that of the experiment group with 98 .0% (P<0 .05) .CONCLUSION PCR examination and combined therapy has high sensitivity and clear curative effect on the clinical diagnosis and treatment of herpes simplex virus keratitis with corneal tissue latently infected by virus ,hence are benefit for the recovery of patients .