CAJ | 학술논문

目的：研究辛伐他汀对动脉粥样硬化（atherosclerosis，AS）模型大鼠主动脉粥样硬化段IL-18， IL-10 mRNA表达的影响。方法雄性SD大鼠高脂饲料喂养，复制食饵性AS早期模型，用药组灌胃辛伐他汀。造模给药4周后，用RT-PCR方法观察对照组、模型组和用药组主动脉壁粥样硬化段病理变化及IL-18，IL-10 mRNA的表达。结果辛伐他汀组AS主动脉硬化段IL-18 mRNA的表达降低，IL-10 mR-NA的表达增加，动脉硬化的进程被阻止。结论辛伐他汀对大鼠动脉粥样硬化具有保护作用，并能提高AS斑块稳定性。
목적：연구신벌타정대동맥죽양경화（atherosclerosis，AS）모형대서주동맥죽양경화단IL-18， IL-10 mRNA표체적영향。방법웅성SD대서고지사료위양，복제식이성AS조기모형，용약조관위신벌타정。조모급약4주후，용RT-PCR방법관찰대조조、모형조화용약조주동맥벽죽양경화단병리변화급IL-18，IL-10 mRNA적표체。결과신벌타정조AS주동맥경화단IL-18 mRNA적표체강저，IL-10 mR-NA적표체증가，동맥경화적진정피조지。결론신벌타정대대서동맥죽양경화구유보호작용，병능제고AS반괴은정성。
Objective To study the effect of simvastatin on expressions of IL-18 , IL-10 mRNA in aortic atherosclerotic segment .Methods Male SD rats were fed with high-fat diet, early di-etary AS model was copied .Treatment group were given simvastatin .After 4 weeks, the ex-pressions of IL-18 , IL-10 mRNA of aortic atherosclerotic segment in control group , model group and treatment group were observed by RT-PCR method .Results In treatment group , expres-sion of IL-18 mRNA on the main section of AS was reduced , expression of IL-10 mRNA in-creased , and AS process was prevented .Conclusion Simvastatin has protective effect on AS , and could improve the stability of AS plaque .