中国卫生标准管理
中國衛生標準管理
중국위생표준관리
CHINA HEALTH STANDARD MANAGEMENT
2015年
9期
14-16
,共3页
熊去氧胆酸%固体分散体%流化床喷雾包衣技术
熊去氧膽痠%固體分散體%流化床噴霧包衣技術
웅거양담산%고체분산체%류화상분무포의기술
Ursodeoxycholic acid%SD%Fluidized bed spraying technology
目的：制备熊去氧胆酸固体分散体片，考察其溶出度。方法将熊去氧胆酸与辅料混合均匀，加入适当浓度的乙醇溶液溶解，采用流化床喷雾包衣技术包载于空白丸芯表面，制得固体分散体小丸，再粉碎后与MCC、PVPP和微粉硅胶混合压片，制得固体分散体片剂，溶出度仪测定固体分散体粉末、固体分散体小丸、固体分散体片的溶出曲线。结果溶出度测定表明，固体分散体片剂的溶出速度显著增大，甚至比相应的粉末还大。结论可以采用将固体分散体小丸粉碎后压片的方式制备熊去氧胆酸固体分散体片。
目的：製備熊去氧膽痠固體分散體片，攷察其溶齣度。方法將熊去氧膽痠與輔料混閤均勻，加入適噹濃度的乙醇溶液溶解，採用流化床噴霧包衣技術包載于空白汍芯錶麵，製得固體分散體小汍，再粉碎後與MCC、PVPP和微粉硅膠混閤壓片，製得固體分散體片劑，溶齣度儀測定固體分散體粉末、固體分散體小汍、固體分散體片的溶齣麯線。結果溶齣度測定錶明，固體分散體片劑的溶齣速度顯著增大，甚至比相應的粉末還大。結論可以採用將固體分散體小汍粉碎後壓片的方式製備熊去氧膽痠固體分散體片。
목적：제비웅거양담산고체분산체편，고찰기용출도。방법장웅거양담산여보료혼합균균，가입괄당농도적을순용액용해，채용류화상분무포의기술포재우공백환심표면，제득고체분산체소환，재분쇄후여MCC、PVPP화미분규효혼합압편，제득고체분산체편제，용출도의측정고체분산체분말、고체분산체소환、고체분산체편적용출곡선。결과용출도측정표명，고체분산체편제적용출속도현저증대，심지비상응적분말환대。결론가이채용장고체분산체소환분쇄후압편적방식제비웅거양담산고체분산체편。
Objective To prepare Ursodeoxycholic Acid SD tablet and observe it’s dissolution rate. Methods Homogeneously mix Ursodeoxycholic Acid and accessories,put ethanol to dissolve,use the technology of fluidized bed spraying to be warped with empty pellets to make solid disperse pel ets,which blend with Mcc、PVPP and Gum Acacia after break into pieces. Make solid disperse pel ets,dissolution of solid disperse powder and solid disperse balls,stripping curve of solid disperse slab. Rseults Dissolution rate shows that the speed of solid disperse pellets increased remarkably,even larger than compared powder. Conclusion The method of pulverizing and tabletting solid disperse bal s could be use to prepare Ursodeoxycholic solid disperse pel ets.
