CAJ | 학술논문

目的：评价中国部分珠蛋白生成障碍性贫血筛查实验室检测血红蛋白 A2和 F 的水平和现状。方法向50家珠蛋白生成障碍性贫血实验室发放两个批号的质控品，收集实验室回报的 HbA2和 HbF 检测值，对回报的结果按照方法分组进行统计分析，并评价其检测水平。结果49家实验室回报了检测结果，回报率为98％。HbA2的及格率为42.9％～92.3％，HbF 的及格率为27.3％～84.6％。通过稳健 Z 比分数统计，血红蛋白 HbA2项目201311批号样本有3家实验室检测结果为不满意，201312批号样本有4家实验室检测结果为不满意，血红蛋白 HbF 项目201311批号样本有5家实验室检测结果为不满意，201312批号样本有3家实验室检测结果为不满意。结论我国珠蛋白生成障碍性贫血筛查实验室检测 HbA2和 HbF 质量有待进一步提高。
목적：평개중국부분주단백생성장애성빈혈사사실험실검측혈홍단백 A2화 F 적수평화현상。방법향50가주단백생성장애성빈혈실험실발방량개비호적질공품，수집실험실회보적 HbA2화 HbF 검측치，대회보적결과안조방법분조진행통계분석，병평개기검측수평。결과49가실험실회보료검측결과，회보솔위98％。HbA2적급격솔위42.9％～92.3％，HbF 적급격솔위27.3％～84.6％。통과은건 Z 비분수통계，혈홍단백 HbA2항목201311비호양본유3가실험실검측결과위불만의，201312비호양본유4가실험실검측결과위불만의，혈홍단백 HbF 항목201311비호양본유5가실험실검측결과위불만의，201312비호양본유3가실험실검측결과위불만의。결론아국주단백생성장애성빈혈사사실험실검측 HbA2화 HbF 질량유대진일보제고。
Objective To evaluate hemoglobin A2 and F (HbA2 and HbF)assays in part of Thalassemia screening laborato-ries in China.Methods Two lots of controls were sent to 50 Thalassemia screening laboratories.Test results of HbA2 and HbF were collected,analyzed and evaluated by different method groups.Results 49 of all laboratories reported the results and the rate of return was 98%.The proportion of laboratories reporting acceptable results for HbA2 and HbF testing was 42.9~92.3% and 27.3% ~ 84.6% respectively.HbA2 test results from 3 laboratories for Lot 201311 and 4 for 201312 were unsatisfactory.And HbF test results from 5 laboratories for Lot 201311 and 3 for 201312 were unsatisfactory.Conclu-sion Conclude that quality in the measurement of HbA2 and HbF should be improved.