CAJ | 학술논문

目的：探讨抗-β2糖蛋白1抗体与女性不孕、先兆流产和月经紊乱之间的关系。方法选取2013年8月～2014年1月在海军总医院辅助医学生殖中心就诊的女性不孕症患者547例、先兆流产患者229例、妇科月经紊乱患者60例和正常孕龄女性31例。应用酶联免疫吸附法（ELISA）对各组的抗-β2糖蛋白1抗体（aβ2GP1）进行检测分析，包括抗-β2糖蛋白1抗体-IgM（aβ2GP1-IgM）和抗-β2糖蛋白1抗体-IgG（aβ2GP1-IgG）。同时选取114例不孕不育及先兆流产患者，检测其经阿司匹林、强的松治疗前后的抗-β2糖蛋白1抗体（Ig-G／Ig-M）。结果健康组、女性不孕组、先兆流产组和月经紊乱组抗-β2糖蛋白1抗体-IgG 的阳性率分别是0％，0.36％，0.43％和1.6％；健康组、月经紊乱组、先兆流产组和女性不孕组抗-β2糖蛋白1抗体-IgM 的阳性率为3.2％，8.3％，19.21％和20.29％，女性不孕组、先兆流产组抗-β2糖蛋白1抗体-IgM抗体与对照组差异均具有统计学意义（χ2＝4.87～5.27，P 值均＜0.05）；女性不孕组经阿司匹林联合强的松治疗前后抗-β2糖蛋白1抗体-IgM（47.14±34.85 RU／ml 和31.14±27.64 RU／ml）和抗-β2糖蛋白1抗体-IgG（1.81±3.63 RU／ml 和1.14±1.99 RU／ml），差异具有统计学意义（P 值均＜0.01），先兆流产组经阿司匹林联合强的松治疗前后抗-β2糖蛋白1抗体-IgM（37.75±31.20 RU／ml 和24.34±24.48 RU／ml）差异具有统计学意义（P 值均＜0.01），抗-β2糖蛋白1抗体-IgG （1.45±1.76 RU／ml 和1.32±1.52 RU／ml）差异无统计学意义（P 值＝0.718）。结论抗-β2糖蛋白1抗体-IgM 与女性不孕不育及先兆流产有密切相关性，是引起女性不孕及先兆流产的重要因素。
목적：탐토항-β2당단백1항체여녀성불잉、선조유산화월경문란지간적관계。방법선취2013년8월～2014년1월재해군총의원보조의학생식중심취진적녀성불잉증환자547례、선조유산환자229례、부과월경문란환자60례화정상잉령녀성31례。응용매련면역흡부법（ELISA）대각조적항-β2당단백1항체（aβ2GP1）진행검측분석，포괄항-β2당단백1항체-IgM（aβ2GP1-IgM）화항-β2당단백1항체-IgG（aβ2GP1-IgG）。동시선취114례불잉불육급선조유산환자，검측기경아사필림、강적송치료전후적항-β2당단백1항체（Ig-G／Ig-M）。결과건강조、녀성불잉조、선조유산조화월경문란조항-β2당단백1항체-IgG 적양성솔분별시0％，0.36％，0.43％화1.6％；건강조、월경문란조、선조유산조화녀성불잉조항-β2당단백1항체-IgM 적양성솔위3.2％，8.3％，19.21％화20.29％，녀성불잉조、선조유산조항-β2당단백1항체-IgM항체여대조조차이균구유통계학의의（χ2＝4.87～5.27，P 치균＜0.05）；녀성불잉조경아사필림연합강적송치료전후항-β2당단백1항체-IgM（47.14±34.85 RU／ml 화31.14±27.64 RU／ml）화항-β2당단백1항체-IgG（1.81±3.63 RU／ml 화1.14±1.99 RU／ml），차이구유통계학의의（P 치균＜0.01），선조유산조경아사필림연합강적송치료전후항-β2당단백1항체-IgM（37.75±31.20 RU／ml 화24.34±24.48 RU／ml）차이구유통계학의의（P 치균＜0.01），항-β2당단백1항체-IgG （1.45±1.76 RU／ml 화1.32±1.52 RU／ml）차이무통계학의의（P 치＝0.718）。결론항-β2당단백1항체-IgM 여녀성불잉불육급선조유산유밀절상관성，시인기녀성불잉급선조유산적중요인소。
Objective To analysis the correlation of the anti-β2 glycoprotein 1 antibodies in female infertility and threatened a-bortion.Methods Selected 547 patients with female infertility,229 patietns with threatened abortion,229 patietns with ir-regular menses and 31 normal female between August 2013 to January 2014.All the anti-β2 glycoprotein 1 antibodies (Ig-G/Ig-M)were detected by ELISA.Detected the anti-β2 glycoprotein 1 antibodies (Ig-G/Ig-M)of 114 patients who treated with aspirin and prednisone combined with gamma globulin.Results The positive rate of anti-β2GP1 antibodies (Ig-G/Ig-M)of female infertility,threatened abortion,irregular menses and normal female were 0.36%,0.43%,1.6%,0% and 20.29%, 19.21%,8.3% and 3.2%,respectively.The positive rate of aβ2GP1-IgM of female infertility,threatened abortion,irregular menses were higher than normal female.The anti-β2GP1-IgM of the treated female infertility were 47.14± 34.85 RU/ml and 31.14±27.64 RU/ml,respectively.The anti-β2GP1-IgM of the treated threatened abortion were 37.75±31.20 RU/ml and 24.34±24.48 RU/ml,respectively.The levels of anti-β2GP1-IgM of the treated patietns were significantly lower than before.Conclusion There was a close relationship between anti-β2GP1-IgM antibodies and female infertility and threatened abortion,anti-β2GP1-IgM antibodies maybe one of the immune factors for female infertility and threatened abortion.