实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2015年
6期
884-887
,共4页
李莉%杜真%杨俊%丁家望%孙劲%张炯%陈万平%李松%吕志阳%陈勇
李莉%杜真%楊俊%丁傢望%孫勁%張炯%陳萬平%李鬆%呂誌暘%陳勇
리리%두진%양준%정가망%손경%장형%진만평%리송%려지양%진용
心房颤动%HMGB1%rs1412125%关联分析%交互作用
心房顫動%HMGB1%rs1412125%關聯分析%交互作用
심방전동%HMGB1%rs1412125%관련분석%교호작용
Atrial fibrillation%HMGB1%rs1412125%Association analysis%Interaction
目的：探讨中国汉族人群HMGB1基因上 rs1412125与心房颤动之间的关联性。方法：收集396例房颤患者（病例组）和726例对照人群（对照组），采用病例对照关联分析研究方法，检测 HMGB1基因上rs1412125与房颤之间的相关性。结果：rs1412125等位基因与基因型分布频率在病例组与对照组中的差异均无统计学意义（等位基因关联分析：观察 P ＝1．05×10－6，矫正 P ＝0．176；基因型关联分析：加性模式矫正P ＝0．146，显性模式矫正P ＝0．162，隐性模式矫正P ＝0．998）。进一步分析显示，rs1412125等位基因C 可显著增加男性风湿性心脏病患者发生房颤的风险（矫正 P ＝2．07×10－4，矫正 OR ＝8．20，95％CI：2．70～25．0）。结论：HMGB1基因上rs1412125与房颤之间不存在独立相关性，但其与性别、风湿性心脏病之间存在交互效应，可显著增加房颤的发病风险。
目的：探討中國漢族人群HMGB1基因上 rs1412125與心房顫動之間的關聯性。方法：收集396例房顫患者（病例組）和726例對照人群（對照組），採用病例對照關聯分析研究方法，檢測 HMGB1基因上rs1412125與房顫之間的相關性。結果：rs1412125等位基因與基因型分佈頻率在病例組與對照組中的差異均無統計學意義（等位基因關聯分析：觀察 P ＝1．05×10－6，矯正 P ＝0．176；基因型關聯分析：加性模式矯正P ＝0．146，顯性模式矯正P ＝0．162，隱性模式矯正P ＝0．998）。進一步分析顯示，rs1412125等位基因C 可顯著增加男性風濕性心髒病患者髮生房顫的風險（矯正 P ＝2．07×10－4，矯正 OR ＝8．20，95％CI：2．70～25．0）。結論：HMGB1基因上rs1412125與房顫之間不存在獨立相關性，但其與性彆、風濕性心髒病之間存在交互效應，可顯著增加房顫的髮病風險。
목적：탐토중국한족인군HMGB1기인상 rs1412125여심방전동지간적관련성。방법：수집396례방전환자（병례조）화726례대조인군（대조조），채용병례대조관련분석연구방법，검측 HMGB1기인상rs1412125여방전지간적상관성。결과：rs1412125등위기인여기인형분포빈솔재병례조여대조조중적차이균무통계학의의（등위기인관련분석：관찰 P ＝1．05×10－6，교정 P ＝0．176；기인형관련분석：가성모식교정P ＝0．146，현성모식교정P ＝0．162，은성모식교정P ＝0．998）。진일보분석현시，rs1412125등위기인C 가현저증가남성풍습성심장병환자발생방전적풍험（교정 P ＝2．07×10－4，교정 OR ＝8．20，95％CI：2．70～25．0）。결론：HMGB1기인상rs1412125여방전지간불존재독립상관성，단기여성별、풍습성심장병지간존재교호효응，가현저증가방전적발병풍험。
Objective To investigate the association of rs1412125 at high-mobility group box 1 (HMGB1) gene with atrial fibrillation (AF) in Chinese Han population. Methods 396 patients with AF and 726 control subjects were recruited to this study. A case-control association analysis was applied to assess the as-sociation between rs1412125 in HMGB1 and AF. Results There were no significant differences in rs1412125 and the frequency of genotype distribution between the study group and the control group (allelic association:object P value was 1.05E-06, adjust P value was 0.176; genotypic association: additive P value was 0.146, dominant P value was 0.162, and recessive P value was 0.998). The interactions analysis showed that rs1412125 allele C increased the risk of AF in male subjects with rheumatic heart disease (adjust P value was 2.07E-04, rectify OR = 8.20, and 95%CI: 2.70-25.0). Conclusions There is no independent genetic association between rs1412125 at HMGB1 and atrial fibrillation. However , the interactions between rs1412125 and both gender and rheumatic heart disease might increase the risk of atrial fibrillation.
