CAJ | 학술논문

本文旨在探讨川芎对血管性抑郁症( vascular depression, VD)脑保护作用的可能机制。通过对近十几年来相关文献的检索研究发现,脑白质损伤是VD的主要病理学改变。川芎具有活血护脑抗抑郁的作用,其作用机制主要包括改善脑血流、调控凋亡基因的表达、抗自由基损伤、降低免疫炎症反应、降低氨基酸兴奋性毒性、调控核录因子кB( nuclear factor-kappa B,NF-кB)表达以及促进神经细胞修复等。目前川芎及其复方制剂在改善脑缺血引起的脑损伤方面疗效虽比较显著,但对于VD脑保护作用仍有待进一步探索研究。
본문지재탐토천궁대혈관성억욱증( vascular depression, VD)뇌보호작용적가능궤제。통과대근십궤년래상관문헌적검색연구발현,뇌백질손상시VD적주요병이학개변。천궁구유활혈호뇌항억욱적작용,기작용궤제주요포괄개선뇌혈류、조공조망기인적표체、항자유기손상、강저면역염증반응、강저안기산흥강성독성、조공핵록인자кB( nuclear factor-kappa B,NF-кB)표체이급촉진신경세포수복등。목전천궁급기복방제제재개선뇌결혈인기적뇌손상방면료효수비교현저,단대우VD뇌보호작용잉유대진일보탐색연구。
This paper aims to explore possible mechanisms of the cerebral protection of Rhizoma Chuanxiong for Vascular Depression(VD). By searching and researching literatures in recent ten years, the authors found that white matter damage is the main pathological change. Rhizoma Chuanxiong can acti-vate blood circulation and protect the brain in anti-depression. The possible mechanisms include several as-pects such as improving cerebral blood flow, regulating the expression of apoptosis gene, fighting against free radical damage,reducing the immune inflammatory response and the toxicity of excitatory amino acids, regulating the expression of NF-кB and promoting restoration of the nerve cells and so on. Although Rhizo-ma Chuanxiong and the compound preparations has significant effect on improving cerebral damage caused by brainischemia, the mechanisms of protective effect on VD still need further exploration.