CAJ | 학술논문

目的：探讨盐酸氨溴索与常见头孢类抗生素的配伍禁忌，为临床合理用药提供参照。方法严格参照药物使用说明，使用不同的方法将注射用盐酸氨溴索溶液与不同头孢类抗生素进行混合，记录反应结果，总结相关影响因素。结果①将溶于100 mL 0.9%氯化钠溶液的头孢类抗生素溶液与盐酸氨溴索注射液混合，混合后产生白色絮状物，溶液浑浊，且静置3 d 后无变化；②将溶于0.9%氯化钠溶液的头孢类抗生素溶液与稀释后的盐酸氨溴索注射液混合，混合后并无浑浊表现，且未发现白色絮状物，但瓶壁上有少量颗粒，静置10 min 后可溶解，反应液澄明，色泽微黄；③头孢类抗生素＋盐酸氨溴索＋氯化钠＋葡萄糖溶液混合，混合后未见浑浊及白色絮状物，仅瓶壁上存在些许颗粒，静置10 min 后溶解，溶液澄明，颜色微黄。结论在联合用药时必须重视药物之间的配伍禁忌，尽最大可能避免不同药物连续输入患者体内。在一种药物输注完毕后，立即冲洗注射器。严格掌握临床新药使用说明，熟记配伍禁忌，强化用药过程的巡视，尽最大可能保障用药安全，提高用药合理性。
목적：탐토염산안추색여상견두포류항생소적배오금기，위림상합리용약제공삼조。방법엄격삼조약물사용설명，사용불동적방법장주사용염산안추색용액여불동두포류항생소진행혼합，기록반응결과，총결상관영향인소。결과①장용우100 mL 0.9%록화납용액적두포류항생소용액여염산안추색주사액혼합，혼합후산생백색서상물，용액혼탁，차정치3 d 후무변화；②장용우0.9%록화납용액적두포류항생소용액여희석후적염산안추색주사액혼합，혼합후병무혼탁표현，차미발현백색서상물，단병벽상유소량과립，정치10 min 후가용해，반응액징명，색택미황；③두포류항생소＋염산안추색＋록화납＋포도당용액혼합，혼합후미견혼탁급백색서상물，부병벽상존재사허과립，정치10 min 후용해，용액징명，안색미황。결론재연합용약시필수중시약물지간적배오금기，진최대가능피면불동약물련속수입환자체내。재일충약물수주완필후，립즉충세주사기。엄격장악림상신약사용설명，숙기배오금기，강화용약과정적순시，진최대가능보장용약안전，제고용약합이성。
Objective To investigate the incompatibility of ambroxol hydrochloride with cephalosporin antibiotic for clinical rational drug use. Methods Strictly according to dispensatory,performed mixing experiments of Ambroxol Hydrochloride Injection with different cephalosporin antibiotic in different ways,then recorded the response results to summer up the relevant influence factors. Results ① White floc was found after mixing injection of cephalosporin antibiotics and ambroxol hydrochloride. The mixed solution was muddy and no change after standing for 3 d. ② The mixture solution of ambroxol hydrochloride injection diluted and solution of cephalosporin antibiotics dissolved in 0.9% Sodium Chloride Solution showed no turbidity or white floc,but a small amount of particles were on bottle wall. The particles can dissolve after 10 min. Then the reaction liquid was clear with yellowish color. ③ The mixture solution of cephalosporin antibiotics + ambroxol hydrochloride + Sodium Chloride + glucose solution no turbidity or white floc,but only some particles were on the bottle wall. And the particles can dissolve after 10 min. Then the reaction liquid was clear with light yellow color. Conclusion When drugs were in combination, we must pay attention to the incompatibility as much as possible,and avoid different drugs in patients with continuous input. Then flushed syringe as soon as drug infusion was completed. Success to master clinical drug use,memorize the incompatibility and strengthen perambulatory medication process so can guarantee drug usage safety and rational.