CAJ | 학술논문

目的：研究不同血尿酸水平人群糖负荷后胰岛素分泌差异，分析胰岛素分泌和血尿酸（SUA）的关系。方法对877例符合要求对象进行生化检查行 OGTT 试验。将研究对象分为尿酸正常组（NUA）和高尿酸组（HUA），比较两组糖负荷后胰岛素（INS）0，30，60，120和180 min（INS0，INS30，INS60，INS120，INS180）分泌差异。以血尿酸水平为因变量行多因素逐步回归分析，分析血尿酸水平影响因素。结果 HUA 组男性女性0，30，60，120和180 min 胰岛素分泌均高于NUA 组（P 均＜0.05）；糖负荷后各时段 INS 分泌与 SUA 水平 Pearson 相关系数分别为0.107，0.154，0.195，0.157和0.112（P ＜0.01）。多因素逐步回归分析显示 SUA 的影响因素有女性，INS60，TC，HDL（β值－0.214，0.194，0.253和－0.119，P ＜0.01）。结论糖负荷后的 HUA 组各时段 INS 分泌高于 NUA 组，INS 分泌与 SUA 水平正相关；INS60，TC 与SUA 水平正相关，性别（女性）、HDL 与 SUA 负相关。提示或可将空腹 SUA 作为 INS（尤其是 INS60）分泌潜在标志物运用于临床。
목적：연구불동혈뇨산수평인군당부하후이도소분비차이，분석이도소분비화혈뇨산（SUA）적관계。방법대877례부합요구대상진행생화검사행 OGTT 시험。장연구대상분위뇨산정상조（NUA）화고뇨산조（HUA），비교량조당부하후이도소（INS）0，30，60，120화180 min（INS0，INS30，INS60，INS120，INS180）분비차이。이혈뇨산수평위인변량행다인소축보회귀분석，분석혈뇨산수평영향인소。결과 HUA 조남성녀성0，30，60，120화180 min 이도소분비균고우NUA 조（P 균＜0.05）；당부하후각시단 INS 분비여 SUA 수평 Pearson 상관계수분별위0.107，0.154，0.195，0.157화0.112（P ＜0.01）。다인소축보회귀분석현시 SUA 적영향인소유녀성，INS60，TC，HDL（β치－0.214，0.194，0.253화－0.119，P ＜0.01）。결론당부하후적 HUA 조각시단 INS 분비고우 NUA 조，INS 분비여 SUA 수평정상관；INS60，TC 여SUA 수평정상관，성별（녀성）、HDL 여 SUA 부상관。제시혹가장공복 SUA 작위 INS（우기시 INS60）분비잠재표지물운용우림상。
Objective To explore the relationship between fasting serum concentration of uric acid (SUA)and the secretion of insulin under oral glucose tolerance test(OGTT)in 877 eligible subjects.Methods A 75g OGTT was administrated to all 877 eligible subjects,fasting uric acid,concentration of glucose and insulin of 0,30,60,120 and 180 min utes after OGTT were measured.Subjects were divided into high SUA group (HUA)and normal SUA group (NUA)according the concen-tration of SUA.SPSS 13.0 were used to analyze these data.Results Subjects in HUA had higher concentration of insulin in 0,30,60,120 and 180 min utes than NUA.There were positive correlation between SUA and INS in 0,30,60,120 and 180 min utes,Pearson r-value was 0.107,0.154,0.195,0.157 and 0.112(all P <0.01)respectively.By stepwise linear regression analyze,there were four parameters correlated with SUA:gender(female),INS60,cholesterol (TC),high density lipoprotein (HDL),β-vaule was -0.214,0.194,0.253,-0.119 (all P <0.01)respectively.Conclusion SUA positive correlated with secretion of INS after glycemia burden,SUA may be used as a potential biomark of secretin of INS (especially the concentra-tion of INS 60).