CAJ | 학술논문

目的：研究炎症营养指数（ INI ）与胃癌术后复发的关系，并探讨其对预后的影响。方法：纳入78例术后复发和64例术后无复发的胃癌患者，根据血清白蛋白和 C 反应蛋白比值计算 INI ，分析 INI 与病理特征的关系，采用受试者工作特征（ ROC ）曲线分析 INI 对术后复发的预测价值；运用 Kaplan-Meier 曲线和Cox 回归模型分析 INI 与预后的关系。结果：复发组的 INI 较小，肿瘤直径较大，分化程度较低，浸润较深和 TNM 分期较高，差异均有统计学意义（均 P ＜0．01）；INI 预测胃癌复发的敏感度为62．5％，特异度为79．5％，临界值为0．36，有统计学意义（P ＜0．01）；低 INI 组的病理特征均差于高 INI 组，差异均有统计学意义（均 P ＜0．01）； INI 预测胃癌预后的敏感度为65．9％，特异度为66．8％，临界值为0．34，有统计学意义（P ＜0．01）；低 INI 组预后差于高 INI 组（48．8％ vs 25．0％，P ＜0．01），INI 是胃癌预后的独立危险因素（OR ＝1．78，95％ CI：1．34～2．59，P ＜0．01）。结论：INI 与胃癌的病变特征紧密相关，是判断胃癌复发和预后的有效指标。
목적：연구염증영양지수（ INI ）여위암술후복발적관계，병탐토기대예후적영향。방법：납입78례술후복발화64례술후무복발적위암환자，근거혈청백단백화 C 반응단백비치계산 INI ，분석 INI 여병리특정적관계，채용수시자공작특정（ ROC ）곡선분석 INI 대술후복발적예측개치；운용 Kaplan-Meier 곡선화Cox 회귀모형분석 INI 여예후적관계。결과：복발조적 INI 교소，종류직경교대，분화정도교저，침윤교심화 TNM 분기교고，차이균유통계학의의（균 P ＜0．01）；INI 예측위암복발적민감도위62．5％，특이도위79．5％，림계치위0．36，유통계학의의（P ＜0．01）；저 INI 조적병리특정균차우고 INI 조，차이균유통계학의의（균 P ＜0．01）； INI 예측위암예후적민감도위65．9％，특이도위66．8％，림계치위0．34，유통계학의의（P ＜0．01）；저 INI 조예후차우고 INI 조（48．8％ vs 25．0％，P ＜0．01），INI 시위암예후적독립위험인소（OR ＝1．78，95％ CI：1．34～2．59，P ＜0．01）。결론：INI 여위암적병변특정긴밀상관，시판단위암복발화예후적유효지표。
Objective To investigate the correlation between the inflammatory-nutritional index (INI) and recurrence and prognosis in patients with gastric cancer. Methods A total of 78 cases patients of gastric cancer with recurrence and 64 cases without recurrence were enrolled. INI was calculated by the ratio of serum albumin and C-reactive protein. The value of INI predicting recurrence was analyzed using receiver operating characteristic curve (ROC). According to this value, the Kaplan-Meier curves and Cox regression analysis were used to evaluate the effect of INI on prognosis. Results Compared with the control group, the recurrence group showed smaller INI, larger tumors, lower degree of differentiation, deeper invasion and higher TNM stage, the differences were statistically significant (all P < 0.01); The INI significantly predicted the recurrence of gastric cancer, with a sensitivity of 62.5%, specificity of 79.5% and critical value of 0.36 (P < 0.01); Additionally, The pathological features were worse in the low INI group than the high INI group , the differences were statistically significant (P < 0.01); The INI significantly predicted the prognosis of gastric cancer, with a sensitivity of 65.9%, specificity of 66.8% and the critical value of 0.34 (P < 0.01); Obviously, the survival rate was lower in the low INI group than the high INI group (48.8% vs 25.0%, P < 0.01). Furthermore, INI was an independent risk factor for prognosis of gastric cancer (OR = 1.78, 95% CI: 1.34 ~ 2.59, P < 0.01). Conclusion The INI is closely related to the characteristics of gastric cancer, it is an effective marker to predict recurrence and prognosis of gastric cancer.