CAJ | 학술논문

目的：研究众生丸对H1 N1流感病毒感染小鼠的保护及免疫调节作用。方法以奥司他韦为阳性药,H1N1流感病毒滴鼻感染小鼠复制小鼠病毒性肺炎模型。比较小鼠病毒性肺炎模型的肺指数、肺组织形态学、死亡保护率、小鼠T淋巴细胞亚群和细胞因子干扰素-γ( Interferon-γ, IFN-γ)、白细胞介素-10(interleukin-10, IL-10)的数量变化。结果与病毒对照组比较,众生丸可显著降低H1N1感染小鼠的肺指数,提高存活率,调节T细胞亚群含量,促进血清中IFN-γ和IL-10产生。结论众生丸可通过减轻炎症,调节免疫而减轻H1 N1亚型流感病毒所致小鼠肺部病变,提高染毒小鼠存活率。
목적：연구음생환대H1 N1류감병독감염소서적보호급면역조절작용。방법이오사타위위양성약,H1N1류감병독적비감염소서복제소서병독성폐염모형。비교소서병독성폐염모형적폐지수、폐조직형태학、사망보호솔、소서T림파세포아군화세포인자간우소-γ( Interferon-γ, IFN-γ)、백세포개소-10(interleukin-10, IL-10)적수량변화。결과여병독대조조비교,음생환가현저강저H1N1감염소서적폐지수,제고존활솔,조절T세포아군함량,촉진혈청중IFN-γ화IL-10산생。결론음생환가통과감경염증,조절면역이감경H1 N1아형류감병독소치소서폐부병변,제고염독소서존활솔。
Objective To study the protection and Immunomodulatory mechanism of Zhongsheng Pill on mice infected with H1N1 influenza virus. Methods The model of viral pneumonia was established by dripping H1N1 virus nasally in mice, with Tamiflu as the positive drug. The lung index, histologic and morphologic changes of lungs, survival rate, the levels of T lymphocyte subpopulation, Interferon-γ( IFN-γ) and interleukin-10 ( IL-10 ) in mice model were investigated. Results Compared with the control group, the model group treated with Zhongsheng Pill was shown a reduced level of lung index, increased survival rate, regulated level of T lymphocyte subpopulation, induced production of IFN-γand IL-10. Con-clusion Zhongsheng Pill can improve the survival rate through relieving the inflammation and regulating the immune function to reduce the lung lesions caused by H1N1 influenza virus.