哈尔滨医药
哈爾濱醫藥
합이빈의약
HARBIN MEDICAL JOURNAL
2015年
2期
87-89
,共3页
肾衰竭%认知%胰岛素抵抗
腎衰竭%認知%胰島素牴抗
신쇠갈%인지%이도소저항
Renal failure%Cognition%Insulin resistance
目的：探讨慢性肾衰竭患者认知功能与胰岛素抵抗( IR)关系的研究。方法将72例慢性肾衰竭非透析患者分为两组：合并认知功能损害患者组23例,认知功能正常组49例,比较两组间性别、年龄、BMI、TC、TG、CRP、内生肌酐清除率( CCr)、HOMA-IR、颈动脉内膜中层厚度( Intima-media thickness,IMT)、收缩压( SBP)和舒张压( DBP)的差别,并进行Logis-tic回归分析。结果与认知功能正常组相比,合并认知功能损害患者组BMI、TG、FINS、CRP、IMT及HOMA-IR较高(P<0.05)；Logistic回归分析显示IMT、CCr及HOMA-IR对认知功能障碍的发病具有相关性。结论 HOMA-IR、IMT及CCr是认知功能障碍的独立危险因素。
目的：探討慢性腎衰竭患者認知功能與胰島素牴抗( IR)關繫的研究。方法將72例慢性腎衰竭非透析患者分為兩組：閤併認知功能損害患者組23例,認知功能正常組49例,比較兩組間性彆、年齡、BMI、TC、TG、CRP、內生肌酐清除率( CCr)、HOMA-IR、頸動脈內膜中層厚度( Intima-media thickness,IMT)、收縮壓( SBP)和舒張壓( DBP)的差彆,併進行Logis-tic迴歸分析。結果與認知功能正常組相比,閤併認知功能損害患者組BMI、TG、FINS、CRP、IMT及HOMA-IR較高(P<0.05)；Logistic迴歸分析顯示IMT、CCr及HOMA-IR對認知功能障礙的髮病具有相關性。結論 HOMA-IR、IMT及CCr是認知功能障礙的獨立危險因素。
목적：탐토만성신쇠갈환자인지공능여이도소저항( IR)관계적연구。방법장72례만성신쇠갈비투석환자분위량조：합병인지공능손해환자조23례,인지공능정상조49례,비교량조간성별、년령、BMI、TC、TG、CRP、내생기항청제솔( CCr)、HOMA-IR、경동맥내막중층후도( Intima-media thickness,IMT)、수축압( SBP)화서장압( DBP)적차별,병진행Logis-tic회귀분석。결과여인지공능정상조상비,합병인지공능손해환자조BMI、TG、FINS、CRP、IMT급HOMA-IR교고(P<0.05)；Logistic회귀분석현시IMT、CCr급HOMA-IR대인지공능장애적발병구유상관성。결론 HOMA-IR、IMT급CCr시인지공능장애적독립위험인소。
Objective To explore the relationship between cognitive impairment and insulin resistance in non-dialysis patients with chronic renal failure( CRF) . Methods A total of 72 patients with CRF were divided into two groups:cognitive impairment group and non-cognitive impairment group. The weight,body mass index(BMI),fasting serum glucose,insulin,total cholesterol(TC),tri-glyceride( TG) ,intima-media thickness( IMT) and CRP were detected. The difference of these indexes and HOMA-IR were com-pared between cognitive impairment group and non-cognitive impairment group. Results Compared with non-cognitive impairment group,the BMI,FPG,TG,CRP,IMT,CCr and HOMA-IR in cognitive impairment group increased markedly(P<0. 05),CCr was lower. The Logistic regression analysis showed that CCr, HOMA - IR, and CRP had an impact on the incidence of cognitive impairment . Conclusion HOMA-IR,CRP and CCr were the independent risk factors for developing cognitive impairment in pa-tients with chronic kidney disease.
