CAJ | 학술논문

目的：探讨补肾调肝法治疗老年期抑郁的临床疗效。方法以肾虚肝郁型老年期抑郁患者为研究对象，分别采用补肾调肝汤(自拟)加减干预方案及西药盐酸舍曲林口服干预方案，观察期为12周，通过汉密尔顿抑郁量表减分率及中医证候疗效指数判断补肾调肝法对肾虚肝郁型老年期抑郁的临床疗效。结果治疗12周前后补肾调肝汤和盐酸舍曲林组，在汉密尔顿抑郁量表、汉密尔顿焦虑量表、匹兹堡睡眠质量指数及肾虚肝郁量表均有下降( P<0．01)；其中对于汉密尔顿抑郁量表减分率的改善补肾调肝组不如盐酸舍曲林组，但对于汉密尔顿焦虑量表、匹兹堡睡眠质量指数及肾虚肝郁量表的减分率优于盐酸舍曲林组( P<0．01)。结论补肾调肝法治疗老年期抑郁症具有良好的临床疗效，且具有改善睡眠及躯体症状的作用。
목적：탐토보신조간법치료노년기억욱적림상료효。방법이신허간욱형노년기억욱환자위연구대상，분별채용보신조간탕(자의)가감간예방안급서약염산사곡림구복간예방안，관찰기위12주，통과한밀이돈억욱량표감분솔급중의증후료효지수판단보신조간법대신허간욱형노년기억욱적림상료효。결과치료12주전후보신조간탕화염산사곡림조，재한밀이돈억욱량표、한밀이돈초필량표、필자보수면질량지수급신허간욱량표균유하강( P<0．01)；기중대우한밀이돈억욱량표감분솔적개선보신조간조불여염산사곡림조，단대우한밀이돈초필량표、필자보수면질량지수급신허간욱량표적감분솔우우염산사곡림조( P<0．01)。결론보신조간법치료노년기억욱증구유량호적림상료효，차구유개선수면급구체증상적작용。
Objective To investigate the clinical efficacy of Tonifying Kidney and Supplementing Liver therapy for senile depression. Methods Bushen tiaogan ( Tonifying Kidney and Supplementing Liv-er) Decoction, along with Western medicine and sertraline hydrochloride treatment, has been used for 12 weeks on senile depression patients of kidney deficiency and liver qi stagnation type. Clinical efficacy was assessed by the Hamilton Depression Scale ( HAMD) score index and the rate of TCM syndrome curative effects. Results After 12 weeks of treatment, the index of HAMA, HAMD, PSQI as well as the scale of kidney deficiency and liver qi stagnation were reduced in both groups (P<0. 01). Although the rate of re-duction of HAMD in Bushen tiaogan Decoction group was not better than that in sertraline hydrochloride group, the rate of reduction of HAMA, PSQI, kidney deficiency and liver qi stagnation scale in Bushen tiaogan Decoction group was not better than that in sertraline hydrochloride group ( P < 0. 01 ). Conclusion Bushen tiaogan therapy has good clinical efficacy for the treatment of senile depression, and it can also improve the quality of sleep and relieve somatic symptoms.