CAJ | 학술논문

目的：观察氯沙坦和赖诺普利降压、降尿酸作用，为临床治疗方案的选择提供可靠依据。方法对我院2013年2月～2014年2月收纳的58例原发性高血压伴高尿酸血症患者进行回顾性分析，随机将患者均分为对照组与观察组。给予对照组患者赖诺普利进行治疗，给予观察组患者氯沙坦进行治疗。结果经治疗，两组患者血压均明显下降，治疗前后对比差异有统计学意义（P<0.05）。观察组患者血尿酸水平较治疗前明显下降（P<0.05），对照组患者治疗前后血尿酸水平无显著改变（P>0.05），无统计学差异。结论氯沙坦和赖诺普利均具有良好的降压功能，相较于氯沙坦，赖诺普利降尿酸作用并不明显，临床用药应慎重对待。
목적：관찰록사탄화뢰낙보리강압、강뇨산작용，위림상치료방안적선택제공가고의거。방법대아원2013년2월～2014년2월수납적58례원발성고혈압반고뇨산혈증환자진행회고성분석，수궤장환자균분위대조조여관찰조。급여대조조환자뢰낙보리진행치료，급여관찰조환자록사탄진행치료。결과경치료，량조환자혈압균명현하강，치료전후대비차이유통계학의의（P<0.05）。관찰조환자혈뇨산수평교치료전명현하강（P<0.05），대조조환자치료전후혈뇨산수평무현저개변（P>0.05），무통계학차이。결론록사탄화뢰낙보리균구유량호적강압공능，상교우록사탄，뢰낙보리강뇨산작용병불명현，림상용약응신중대대。
Objective To observed the effect of losartan and lisinopril to provide reliable basis for the choice of clinical treatment.Methods In our hospital from February 2013 to February 2014,58 patients with primary hypertension with high uric acid hematic disease were retrospectively analyzed,patients were randomly divided into control group and observation group,to the control group patients treated with lisinopril,giving chlorine sand observation group of patients for treatment.Results Two groups of patients were significantly lower blood pressure,compared before and after treatment was statisticaly significant difference(P<0.05). Observation group of patients was significantly lower the blood uric acid level(P<0.05),the control group patients before and after treatment the blood uric acid level had no significant change(P>0.05),no statistical difference.Conclusion Chlorine sand and lisinopril has good antihypertensive function,compared with chlorine sand,lisinopril uric acid reduction effect is not obvious,clinical medicine should be treated with caution.