CAJ | 학술논문

目的：对临产孕妇念珠菌感染及不良妊娠结局进行调查。方法知情同意下，选择2013年1月～2014年6月，到茂名市妇幼保健院产科住院的542例临产孕妇，采集其阴道分泌物进行念珠菌检查。所选对象年龄段为20～30岁，均自诉无阴道致病原感染不适症状，但包括很小部分表述有阴道念珠菌感染临床表现者。采用10 g／dl 氢氧化钾溶液湿片和革兰氏染色油片两种方法，两法显微镜下同时找到假丝酵母菌的芽生孢子或假菌丝确诊为阳性结果，否则为阴性。分别选择阳性为观察组，阴性为对照组，记录两组孕妇发生胎膜早破、会阴伤口感染、新生儿鹅口疮、新生儿尿布疹四种不良妊娠结局情况。统计学方法：计数资料用卡方检验，计量资料用方差分析。结果获得念珠菌阳性125例，阴性417例，感染率为23.1％，水平较国内报道的19.3％高。观察组孕妇胎膜早破、新生儿尿布疹、会阴伤口感染、新生儿鹅口疮发生率分别是19.2％，8.0％，16.8％和12.8％；明显高于对照组的8.4％，1.2％，3.8％和1.7％（χ2＝12.578～29.273，P 值均＜0.01）。结论孕妇念珠菌感染可增加不良妊娠结局，保健或临床医生应建议孕妇，对该菌行常规检查并及早诊治，以便更好预防不良妊娠结局。
목적：대임산잉부념주균감염급불량임신결국진행조사。방법지정동의하，선택2013년1월～2014년6월，도무명시부유보건원산과주원적542례임산잉부，채집기음도분비물진행념주균검사。소선대상년령단위20～30세，균자소무음도치병원감염불괄증상，단포괄흔소부분표술유음도념주균감염림상표현자。채용10 g／dl 경양화갑용액습편화혁란씨염색유편량충방법，량법현미경하동시조도가사효모균적아생포자혹가균사학진위양성결과，부칙위음성。분별선택양성위관찰조，음성위대조조，기록량조잉부발생태막조파、회음상구감염、신생인아구창、신생인뇨포진사충불량임신결국정황。통계학방법：계수자료용잡방검험，계량자료용방차분석。결과획득념주균양성125례，음성417례，감염솔위23.1％，수평교국내보도적19.3％고。관찰조잉부태막조파、신생인뇨포진、회음상구감염、신생인아구창발생솔분별시19.2％，8.0％，16.8％화12.8％；명현고우대조조적8.4％，1.2％，3.8％화1.7％（χ2＝12.578～29.273，P 치균＜0.01）。결론잉부념주균감염가증가불량임신결국，보건혹림상의생응건의잉부，대해균행상규검사병급조진치，이편경호예방불량임신결국。
Objective To investigate Monilia infection and adverse pregnancy outcomes of pregnant women in labor.Methods Before informed consent,542 cases of pregnant women in labor were collected in Obstetrics Department of Maternity and Child Healthcare of Maoming City from January 2013 to April 2014,and all of these cases were examined by Monilia inspec-tion of vaginal secretions.All of these cases were 20 to 30 years old,without vaginal pathogenic infection symptoms,but in-cluded in a few of formulation of clinical features of vaginal Candida infection.With the two methods of 10% potassium hy-droxide solution wet sheet and Gram staining,if blastospore or pseudohypha of Candida mycoderma were found out in the two methods under microscope,this case was diagnosed as positive result,otherwise as negative result.Respectively choosing positive cases as observation group,and negative cases as control group,the indexes of premature rupture of membranes,per-ineum wound infection,neonatal thrush and neonatal diaper rash of the two groups were recorded.The statistical method:e-numeration data by chi-square test,measurement data using analysis of varianc.Results The positive rate of Monilia was 23.1% (125/542),higher than 19.3% reported in domestic.The incidence rates of neonatal diaper rash,premature rupture of membranes,neonatal thrush and perineum wound infection of the observation group were respectively 19.2%,8.0%, 16.8% and 12.8%,all much higher than the control group respectively was 8.4%,1.2%,3.8% and 1.7%,(χ2 =12.578~29.273,all P <0.01).Conclusion Monilia infection of pregnant women in labor could increase the chance of adverse preg-nancy outcomes.Healthy or clinical doctors should suggest that pregnant women early carry out routine examination and ear-ly treatment,in order to prevent adverse pregnancy outcomes.