CAJ | 학술논문

目的：通过对尿毒症患者血液透析前后血清蛋白成分变化情况的分析，探讨血液透析对机体炎症状态及免疫功能的影响。方法选取2013年10月～2014年5月经肾病内科确诊的尿毒症患者75例为观察组，同期15名健康体检者为对照组，将观察组首次透析前、首次透析后、规律透析治疗一个月后以及对照组的血清蛋白电泳图谱相互进行比较。结果与对照组相比，观察组首次透析前及首次透析后清蛋白水平降低，α1和α2球蛋白水平升高，差异有统计学显著性意义（P ＜0.001）。首次透析后α1球蛋白水平降低，差异有统计学意义（P ＜0.01）。透析治疗一个月后清蛋白与首次透析前的差异无统计学意义（P ＞0.05），而α1和α2球蛋白较透析前明显降低，差异有统计学意义（P ＜0.001），清蛋白低于对照组差异有统计学意义（P ＜0.001），γ球蛋白与对照组、首次透析前及首次透析后比较水平升高，差异均有统计学意义（P ＜0.001或 P ＜0.01）。结论规律有效的血液透析可以改善尿毒症患者机体的炎症状态增强机体免疫功能。
목적：통과대뇨독증환자혈액투석전후혈청단백성분변화정황적분석，탐토혈액투석대궤체염증상태급면역공능적영향。방법선취2013년10월～2014년5월경신병내과학진적뇨독증환자75례위관찰조，동기15명건강체검자위대조조，장관찰조수차투석전、수차투석후、규률투석치료일개월후이급대조조적혈청단백전영도보상호진행비교。결과여대조조상비，관찰조수차투석전급수차투석후청단백수평강저，α1화α2구단백수평승고，차이유통계학현저성의의（P ＜0.001）。수차투석후α1구단백수평강저，차이유통계학의의（P ＜0.01）。투석치료일개월후청단백여수차투석전적차이무통계학의의（P ＞0.05），이α1화α2구단백교투석전명현강저，차이유통계학의의（P ＜0.001），청단백저우대조조차이유통계학의의（P ＜0.001），γ구단백여대조조、수차투석전급수차투석후비교수평승고，차이균유통계학의의（P ＜0.001혹 P ＜0.01）。결론규률유효적혈액투석가이개선뇨독증환자궤체적염증상태증강궤체면역공능。
Objective To study the influence of hemodialysis on inflammatory state and immune function by analyzing the change of serum protein components in uremic patients before and after hemodialysis.Methods 75 cases of uremic patients confirmed by the Nephrology from October 2013 to May 2014 were selected as the observation group,and 15 healthy volun-teers at the same time as the control group.Then the serum protein electrophoresis pattern of observation group beford the first hemodialysis,after the first hemodialysis,after one month’s treatment and control group were compared with each oth-er.Results In the observation group before and after the first hemodialysis,the ALB levels were lower,α1 and α2 globulin levels were higher than those in control group.There was a statistically significant between the observation group before and after the first hemodialysis and control group (P <0.001).After the first hemodialysis,there were differences inα1 globulin levels compared with before the first hemodialysis (P <0.01).ALB was no significant difference after one month’s hemodi-alysis compared with before the first hemodialysis,andα1,α2 globulin were significantly reduced and the difference was sta-tistically significant (P <0.001),ALB was lower than the control group and was statistically significant (P <0.001).After one month’s hemodialysis,the levels ofγglobulin were higher than those in control group,before the first hemodialysis and after the first hemodialysis.There were significant differences (P <0.001 or P <0.01).Conclusion Regular and effective hemodialysis can improve inflammatory state and immune function of uremic patients.