CAJ | 학술논문

目的：探讨尿液脑钠肽（NT-proBNP）水平在慢性心力衰竭诊断中是否与血液 NT-proBNP 水平具有相似的诊断价值。方法以79例慢性心力衰竭患者（ NYHAⅠ～Ⅳ级）作为研究组，53例健康体检者作为健康对照组，使用德国罗氏公司生产的 cobas h 232心脏标志物检测仪分别对两组尿液和血液 NT-proBNP 水平进行检测，并比较两组尿液 NT-proBNP 与血液 NT-proBNP 水平之间的差异。结果慢性心力衰竭患者组的尿液 NT-proBNP 和血液 NT-proBNP 水平均高于健康对照组，差异具有统计学意义（P ＜0.01）。随心功能 NYHA 分级的增高，尿液 NT-proBNP 水平逐渐升高。尿液 NT-proBNP 水平与血液 NT-proBNP 水平呈正相关。结论尿液 NT-proBNP 水平在慢性心力衰竭诊断中具有重要的临床意义，与血液 NT-proBNP 水平具有相似的诊断价值。
목적：탐토뇨액뇌납태（NT-proBNP）수평재만성심력쇠갈진단중시부여혈액 NT-proBNP 수평구유상사적진단개치。방법이79례만성심력쇠갈환자（ NYHAⅠ～Ⅳ급）작위연구조，53례건강체검자작위건강대조조，사용덕국라씨공사생산적 cobas h 232심장표지물검측의분별대량조뇨액화혈액 NT-proBNP 수평진행검측，병비교량조뇨액 NT-proBNP 여혈액 NT-proBNP 수평지간적차이。결과만성심력쇠갈환자조적뇨액 NT-proBNP 화혈액 NT-proBNP 수평균고우건강대조조，차이구유통계학의의（P ＜0.01）。수심공능 NYHA 분급적증고，뇨액 NT-proBNP 수평축점승고。뇨액 NT-proBNP 수평여혈액 NT-proBNP 수평정정상관。결론뇨액 NT-proBNP 수평재만성심력쇠갈진단중구유중요적림상의의，여혈액 NT-proBNP 수평구유상사적진단개치。
Objective To investigate the value of the levels of urinary NT-proBNP whether is similar with the levels of blood NT-proBNP for the diagnosis of chronic heart failure.Methods 79 patients with chronic heart failure (NYHA Ⅰ~Ⅳ)as a research group,and 53 healthy people as a control group,the levels of urinary and blood NT-proBNP on two groups were measured respectively by Roche cobas h 232 cardiac markers detector and compared the difference of the levels of urinary NT-proBNP and blood NT-proBNP between the two groups.Results The levels of urinary and blood NT-proBNP in pa-tients with chronic heart failure were much higher than those in healthy subjects,respectively (P <0.01).The concentration of urinary NT-proBNP increased gradually with more severe symptoms.The level of urinary NT-proBNP was positively cor-related with the levels of blood NT-proBNP.Conclusion The levels of urinary NT-proBNP is a new candidate marker for the diagnosis of chronic heart failures and it provides a similar accuracy with the levels of blood.