CAJ | 학술논문

目的：比较同型半胱氨酸（homocysteine，HCY）、糖化血红蛋白（glycosylated hemoglobin，HbA1c）、脂类等与后循环缺血的关系，探讨其水平在后循环缺血疾病的临床意义。方法对140例临床诊断为后循环缺血患者和正常健康对照组，清晨空腹采集静脉血样，测定 HCY，HbA1c，总胆固醇（TC），三酰甘油（TG），高密度脂蛋白胆固醇（HDL-C）及低密度脂蛋白胆固醇（LDL-C）水平，比较受试组和对照组的差异。结果经两独立样本 t 检验，后循环缺血患者 HCY 和 HbA1c均明显高于对照组（P ＜0.001）；HDL-C 则明显低于对照组（P ＝0.001），差异有统计学意义，其余脂类指标与对照组比较差异均无统计学意义。Spearman 秩相关分析显示受试者年龄与 HCY 水平（P ＜0.001）呈显著正相关，和 TG 水平（P ＝0.013）呈显著负相关；HCY 与 TG 水平（P ＝0.028）呈显著负相关；HbA1c 与 TG 水平（P ＝0.001）和 LDL-C 水平（P ＝0.027）呈显著正相关。结论HCY 和 HbA1c 水平升高与后循环缺血密切相关，提示了应高度重视 HCY 和 HbA1c 对于有效防治后循环缺血疾病以及改善其预后有重要的意义。
목적：비교동형반광안산（homocysteine，HCY）、당화혈홍단백（glycosylated hemoglobin，HbA1c）、지류등여후순배결혈적관계，탐토기수평재후순배결혈질병적림상의의。방법대140례림상진단위후순배결혈환자화정상건강대조조，청신공복채집정맥혈양，측정 HCY，HbA1c，총담고순（TC），삼선감유（TG），고밀도지단백담고순（HDL-C）급저밀도지단백담고순（LDL-C）수평，비교수시조화대조조적차이。결과경량독립양본 t 검험，후순배결혈환자 HCY 화 HbA1c균명현고우대조조（P ＜0.001）；HDL-C 칙명현저우대조조（P ＝0.001），차이유통계학의의，기여지류지표여대조조비교차이균무통계학의의。Spearman 질상관분석현시수시자년령여 HCY 수평（P ＜0.001）정현저정상관，화 TG 수평（P ＝0.013）정현저부상관；HCY 여 TG 수평（P ＝0.028）정현저부상관；HbA1c 여 TG 수평（P ＝0.001）화 LDL-C 수평（P ＝0.027）정현저정상관。결론HCY 화 HbA1c 수평승고여후순배결혈밀절상관，제시료응고도중시 HCY 화 HbA1c 대우유효방치후순배결혈질병이급개선기예후유중요적의의。
Objective To explore the relationship between homocysteine(HCY),glycosylated hemoglobin(HbA1c),lipids and posterior circulation ischemia and the clinical significance of their levels in the posterior circulation ischemic (PCI)diseases. Methods Difference between PCI were diagnosed in 140 examinees and a healthy control group,with fasting serum,HCY, HbA1c,total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C)and low-density lipoprotein cholesterol (LDL-C)were detected.Results HCY and HbA1c were significantly higher,HDL-C was significantly lower in the patients with PCI,two independent sample t-test showed a significant difference between the test group and control group (P <0.001 and P =0.001),the remaining lipid indicators was not statistically significant.Spearman rank correlation analysis showed that HCY levels had significant positive correlation (P <0.001)and TG levels had significant negative cor-relation (P =0.013)with the subjects age,HCY levels had significant negative correlation with TG levels(P = 0.028), HbA1c levels had significant positive correlation with TG levels and LDL-C levels(P =0.001 and P =0.027).Conclusion High levels of HCY and HbA1c were closely associated with PCI,which HCY and HbA1c should be attached great impor-tance to the effective prevention and treatment and improve of PCI.