CAJ | 학술논문

目的：研究肺癌患者化疗前后凝血、纤溶功能及血小板参数的变化及其临床意义。方法56例肺癌患者肺癌患者化疗前后凝血、纤溶功能及血小板参数的变化被检测，并以56例健康体检者作为对照。结果肺癌患者血浆纤维蛋白原、血小板计数和血小板体积分布宽度分别为（4.31±0.75）g·L-1、（287.41±97.56）×109·L-1和16.01±2.86 fl，健康体检者分别为（3.19±0.46）g·L-1、（205.62±51.97）×109·L-1和（15.12±1.57）fl，比较差异均有统计学意义（ P均＜0.05）。化疗后肺癌患者凝血酶原时间由化疗前的（11.35±0.86）s减少为（10.21±0.65）s，血小板计数由（287.41±97.56）×109·L-1减少为（207.05
목적：연구폐암환자화료전후응혈、섬용공능급혈소판삼수적변화급기림상의의。방법56례폐암환자폐암환자화료전후응혈、섬용공능급혈소판삼수적변화피검측，병이56례건강체검자작위대조。결과폐암환자혈장섬유단백원、혈소판계수화혈소판체적분포관도분별위（4.31±0.75）g·L-1、（287.41±97.56）×109·L-1화16.01±2.86 fl，건강체검자분별위（3.19±0.46）g·L-1、（205.62±51.97）×109·L-1화（15.12±1.57）fl，비교차이균유통계학의의（ P균＜0.05）。화료후폐암환자응혈매원시간유화료전적（11.35±0.86）s감소위（10.21±0.65）s，혈소판계수유（287.41±97.56）×109·L-1감소위（207.05
Objective To research the changes of coagulation,fibrinolysis function and platelet parameters of pa-tients with lung cancer and their clinical significance. Methods The changes of coagulation,fibrinolysis function and platelet parameters of the 56 patients with lung cancer were detected before and after treatment,and those of the healthy volunteers were detected too. Results The fibrinogen,platelets and platelet distribution width of the patients with lung cancer were(4. 31 ± 0. 75)g·L-1 ,(287. 41 ± 97. 56)× 109 ·L-1 and(16. 01 ± 2. 86)fl;those of the healthy volunteers were(3.19±0.46)g·L-1,(205.62 ±51.97)×109·L-1 and(15.12 ±1.57)fl(P<0. 05). After the chemotherapy,the prothrombin time of patients with lung cancer decreased from(11. 35 ± 0. 86)s to(10.21 ± 0. 65)s,the platelets decreased from(287. 41 ± 97. 56)× 109 ·L-1 to(207. 05 ± 81. 36)× 109·L-1,the hemoglobin decreased from(125.79 ±31.08)g·L-1 to(108.20 ±25.74)g·L-1(P<0.05). Conclusion The chemotherapy can induce the changes of coagulation and fibrinolysis function of the patients with lung cancer.