中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2015年
2期
189-192
,共4页
崔洪雨%王振华%王承敏%施梅
崔洪雨%王振華%王承敏%施梅
최홍우%왕진화%왕승민%시매
DNA甲基化%情感障碍%表观遗传
DNA甲基化%情感障礙%錶觀遺傳
DNA갑기화%정감장애%표관유전
DNA methylation%Affective disorder%Epigenetics
目的 DNA甲基化成为近年来表观遗传学的研究热点.越来越多的研究表明DNA甲基化在情感障碍的发病中也扮演着重要角色.本文综述了DNA甲基化的分子机制,介绍了DNA甲基化与情感障碍的关系,并在此基础上对重性抑郁症与双相情感障碍相关基因DNA甲基化的最新研究进展进行了综述.方法 检索2013年6月至2015年1月PUBMED数据库,外文医学信息资源检索平台,CNKI,万方数据库等数据库的相关文章.检索式TI:[depression OR bipolar disorder OR affective disorder] AND All field:DNA methylation.摘要阅读,缩小文献范围.了解实验设计思路,如:样本为血细胞或脑实质中的DNA,甲基化检测方法,检测基因以及甲基化位点等.所得文献英文168篇,中文32篇.阅读全文,保留近5年有关重性抑郁症及双相障碍相关基因的DNA甲基化文献.结果 最终确定29篇文章其中2篇中文文章.大部分是与疾病相关受体基因的表观遗传学研究.结论 重性抑郁症和双相障碍与GR、BDNF、5-HTR、SLC6A4等多个基因启动子区DNA甲基化水平升高及COMT基因启动子区甲基化水平降低有关.本文仅从情感障碍的角度综述了DNA甲基化与疾病的关系,对其他精神疾病的表观遗传研究涉及较少,有待今后完善.
目的 DNA甲基化成為近年來錶觀遺傳學的研究熱點.越來越多的研究錶明DNA甲基化在情感障礙的髮病中也扮縯著重要角色.本文綜述瞭DNA甲基化的分子機製,介紹瞭DNA甲基化與情感障礙的關繫,併在此基礎上對重性抑鬱癥與雙相情感障礙相關基因DNA甲基化的最新研究進展進行瞭綜述.方法 檢索2013年6月至2015年1月PUBMED數據庫,外文醫學信息資源檢索平檯,CNKI,萬方數據庫等數據庫的相關文章.檢索式TI:[depression OR bipolar disorder OR affective disorder] AND All field:DNA methylation.摘要閱讀,縮小文獻範圍.瞭解實驗設計思路,如:樣本為血細胞或腦實質中的DNA,甲基化檢測方法,檢測基因以及甲基化位點等.所得文獻英文168篇,中文32篇.閱讀全文,保留近5年有關重性抑鬱癥及雙相障礙相關基因的DNA甲基化文獻.結果 最終確定29篇文章其中2篇中文文章.大部分是與疾病相關受體基因的錶觀遺傳學研究.結論 重性抑鬱癥和雙相障礙與GR、BDNF、5-HTR、SLC6A4等多箇基因啟動子區DNA甲基化水平升高及COMT基因啟動子區甲基化水平降低有關.本文僅從情感障礙的角度綜述瞭DNA甲基化與疾病的關繫,對其他精神疾病的錶觀遺傳研究涉及較少,有待今後完善.
목적 DNA갑기화성위근년래표관유전학적연구열점.월래월다적연구표명DNA갑기화재정감장애적발병중야분연착중요각색.본문종술료DNA갑기화적분자궤제,개소료DNA갑기화여정감장애적관계,병재차기출상대중성억욱증여쌍상정감장애상관기인DNA갑기화적최신연구진전진행료종술.방법 검색2013년6월지2015년1월PUBMED수거고,외문의학신식자원검색평태,CNKI,만방수거고등수거고적상관문장.검색식TI:[depression OR bipolar disorder OR affective disorder] AND All field:DNA methylation.적요열독,축소문헌범위.료해실험설계사로,여:양본위혈세포혹뇌실질중적DNA,갑기화검측방법,검측기인이급갑기화위점등.소득문헌영문168편,중문32편.열독전문,보류근5년유관중성억욱증급쌍상장애상관기인적DNA갑기화문헌.결과 최종학정29편문장기중2편중문문장.대부분시여질병상관수체기인적표관유전학연구.결론 중성억욱증화쌍상장애여GR、BDNF、5-HTR、SLC6A4등다개기인계동자구DNA갑기화수평승고급COMT기인계동자구갑기화수평강저유관.본문부종정감장애적각도종술료DNA갑기화여질병적관계,대기타정신질병적표관유전연구섭급교소,유대금후완선.
Objective Recent years,epigenetics research mainly focused on DNA methylation.A growing body of research indicated that DNA methylation may play vital role in etiology of affective disorder.With brief introduction of DNA methylation molecular mechanisms and relevance of DNA methylation to affective disorder,this review focuses on some supporting evidence which are recently emerged in major depressive disorder (MDD) and bipolar disorder related gene DNA methylation.Methods We retrievaled related articles from databases,such as PUBMED,Foreign medical information resources retrieval platform,CNKI,Wanfang database,ect,from 2013-06 to 2015-01.Index strategy TI:[depression OR bipolar disorder OR affective disorder] AND All field:DNA methylation.Reading and narrowing the scope of the articles,the experimental design was understanded,such as DNA from either blood cell or brain parenchyma of sample,methods of methylation detection,gene detected and methylation position,etc.The articles included 168 in English and 32 in Chinese.The whole and retained the articles were red about MDD and bipolar disorder related gene DNA methylation in recent five years.Results Eventually,the article includes 29 articles and two of in Chinese.Most of them are receptor gene epigenetics research associated with disease.Conclusion MDD and bipolar disorder are associated with the higher of DNA methylation levels in multiple gene promoter region,such as GR,BDNF,5-HTR,SLC6A4 and the lower of COMT.This article only from the perspective of affective disorder reviewed the relationship between DNA methylation and diseases.None of other diseases epigenetics research,there is to be perfected in future.
