中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2015年
2期
124-127
,共4页
崔立谦%陈壮飞%曹莉萍%邓文皓%邹文锦%林鄞%黄燕萍%余金龙%宁玉萍
崔立謙%陳壯飛%曹莉萍%鄧文皓%鄒文錦%林鄞%黃燕萍%餘金龍%寧玉萍
최립겸%진장비%조리평%산문호%추문금%림은%황연평%여금룡%저옥평
双相障碍%网络%小世界%功能连接
雙相障礙%網絡%小世界%功能連接
쌍상장애%망락%소세계%공능련접
Bipolar disorder%Network%Small world%Functional connectivity
目的 采用图论分析方法探讨早期阶段双相障碍Ⅰ型躁狂患者脑功能网络小世界属性的特点及其与临床资料的关系.方法 对符合美国精神障碍诊断统计手册第4版(DSM-Ⅳ)诊断标准的双相Ⅰ型躁狂发作且病程小于2年的患者22例及性别、年龄与患者匹配的正常健康对照22例进行静息态磁共振扫描,以贝克-拉范森躁狂评定量表(BRMS)评估患者临床症状,在Matlab平台上应用SPM及DPARSF软件提取AAL90个脑区的时间序列,采用Gretna工具包建立功能连接矩阵并计算网络参数,采用双样本t检验比较两组差异.结果 与正常对照组相比,双相Ⅰ型躁狂组在较宽稀疏度范围内(稀疏度为13％,16％～31％)特征路径长度显著大于对照组(P＜0.05),全局效率在稀疏度为18％时显著低于对照组(P＜0.05);稀疏度阈值为18％时,双相Ⅰ型躁狂组BRMS量表分与特征路径长度成正相关(r=0.426,P=0.048)、与全局效率成负相关.结论 患者脑功能网络呈现网络效率下降、特征路径减小等整体性改变,反映了皮质和皮质下连接的异常.特征路径长度及全局效率可能作为病情客观诊断的神经影像标记.
目的 採用圖論分析方法探討早期階段雙相障礙Ⅰ型躁狂患者腦功能網絡小世界屬性的特點及其與臨床資料的關繫.方法 對符閤美國精神障礙診斷統計手冊第4版(DSM-Ⅳ)診斷標準的雙相Ⅰ型躁狂髮作且病程小于2年的患者22例及性彆、年齡與患者匹配的正常健康對照22例進行靜息態磁共振掃描,以貝剋-拉範森躁狂評定量錶(BRMS)評估患者臨床癥狀,在Matlab平檯上應用SPM及DPARSF軟件提取AAL90箇腦區的時間序列,採用Gretna工具包建立功能連接矩陣併計算網絡參數,採用雙樣本t檢驗比較兩組差異.結果 與正常對照組相比,雙相Ⅰ型躁狂組在較寬稀疏度範圍內(稀疏度為13％,16％～31％)特徵路徑長度顯著大于對照組(P＜0.05),全跼效率在稀疏度為18％時顯著低于對照組(P＜0.05);稀疏度閾值為18％時,雙相Ⅰ型躁狂組BRMS量錶分與特徵路徑長度成正相關(r=0.426,P=0.048)、與全跼效率成負相關.結論 患者腦功能網絡呈現網絡效率下降、特徵路徑減小等整體性改變,反映瞭皮質和皮質下連接的異常.特徵路徑長度及全跼效率可能作為病情客觀診斷的神經影像標記.
목적 채용도론분석방법탐토조기계단쌍상장애Ⅰ형조광환자뇌공능망락소세계속성적특점급기여림상자료적관계.방법 대부합미국정신장애진단통계수책제4판(DSM-Ⅳ)진단표준적쌍상Ⅰ형조광발작차병정소우2년적환자22례급성별、년령여환자필배적정상건강대조22례진행정식태자공진소묘,이패극-랍범삼조광평정량표(BRMS)평고환자림상증상,재Matlab평태상응용SPM급DPARSF연건제취AAL90개뇌구적시간서렬,채용Gretna공구포건립공능련접구진병계산망락삼수,채용쌍양본t검험비교량조차이.결과 여정상대조조상비,쌍상Ⅰ형조광조재교관희소도범위내(희소도위13％,16％～31％)특정로경장도현저대우대조조(P＜0.05),전국효솔재희소도위18％시현저저우대조조(P＜0.05);희소도역치위18％시,쌍상Ⅰ형조광조BRMS량표분여특정로경장도성정상관(r=0.426,P=0.048)、여전국효솔성부상관.결론 환자뇌공능망락정현망락효솔하강、특정로경감소등정체성개변,반영료피질화피질하련접적이상.특정로경장도급전국효솔가능작위병정객관진단적신경영상표기.
Objective To explore the small world characters of patients in the early stage of bipolar disorder by using graph theory.Methods Resting-state fMRI data were collected from 22 patients who met with DSMⅣ diagnostic criteria for current manic episode and with duration less than 2 years,and 22 age-and gendermatched healthy control subject.Time series of AAL 90 regions were extracted for each subject and correlation matrices were analyzed.Results Compared with health controls,bipolar disorder patients showed significantly decreased global efficiency in sparsity threshold of 18％ and longer characterized path length in sparsity threshold of 13％,16％-31％ (P＜0.05).BRMS score was positively correlated with characterized path length (r=0.426,P=0.048) and negatively correlated with global efficiency (r=-0.426,P=0.048)in sparsity threshold of 18％ in bipolar manic patients.Conclusion The alteration of global efficiency and characterized path length reflected abnomality of connection between cortical and sub-cortical regions.Characterized path length could be a possible neuroimaging marker of bipolar-I mania.
