CAJ | 학술논문

目的：探讨单一高强度持续刺激导致的创伤后应激障碍(PTSD)患者急性期全脑白质微细结构的改变。方法分别对矿难中17例幸存者(PTSD 组)及17例正常对照者(对照组)进行全脑扩散张量成像(DTI)扫描,应用基于纤维骨架的空间统计方法(TBSS)以及非参数的随机排列检验(RPT)的方法对2组被试者全脑 DTI 的平均扩散度(MD)值数据进行比较,得出有差异的脑区。结果与对照组比较,急性 PTSD 组左侧前放射冠及双侧胼胝体嘴部、膝部 MD 值增高,而双侧上放射冠、后放射冠、左侧内囊后肢、左侧大脑脚、左侧丘脑的 MD 值较正常组减低,其差异均有统计学意义(P 值均<0.01,TFCE 校正)。结论TBSS 方法能较全面、准确地分析 PTSD 患者早期脑白质 DTI 改变,可为 PTSD 的早期发现和早期干预提供客观有效的脑部病理性神经结构影像学评价指标。
목적：탐토단일고강도지속자격도치적창상후응격장애(PTSD)환자급성기전뇌백질미세결구적개변。방법분별대광난중17례행존자(PTSD 조)급17례정상대조자(대조조)진행전뇌확산장량성상(DTI)소묘,응용기우섬유골가적공간통계방법(TBSS)이급비삼수적수궤배렬검험(RPT)적방법대2조피시자전뇌 DTI 적평균확산도(MD)치수거진행비교,득출유차이적뇌구。결과여대조조비교,급성 PTSD 조좌측전방사관급쌍측변지체취부、슬부 MD 치증고,이쌍측상방사관、후방사관、좌측내낭후지、좌측대뇌각、좌측구뇌적 MD 치교정상조감저,기차이균유통계학의의(P 치균<0.01,TFCE 교정)。결론TBSS 방법능교전면、준학지분석 PTSD 환자조기뇌백질 DTI 개변,가위 PTSD 적조기발현화조기간예제공객관유효적뇌부병이성신경결구영상학평개지표。
Objective To detect the changes of the brain white matter microstructure at the acute stage of posttraumatic stress disorder(PTSD)resulting from a single,extreme and long-lasting trauma.Methods DTI scans were performed on 1 7 survivors of coal mine disaster(PTSD group)and 1 7 cases of normal control(control group).The differences of the mean diffusivity(MD)values measured from the whole brain DTI between the two groups were analyzed based on tract based spatial statistics (TBSS).MD data were statistically compared between the two groups based on nonparametric random permutation test(RPT),and the brain areas of significant differences between the two groups were obtained.Results Compared with the control group,MD values were increased in the bilateral rostral corpus callosum body and left precorona radiata,and decreased in the bilateral superior and posterior corona ra-diate,posterior limb of the left internal capsule,left cerebral peduncle and left thalamic.The differences were statistically significant (P <0.01 TFCE-corrected).Conclusion TBSS is a comprehensive and accurate method for evaluate the changes of brain white mat-ter in PTSD cases.TBSS can provide an objective basis of the pathological brain neural structures imaging for early diagnosis and in-tervention of PTSD.