CAJ | 학술논문

目的：探讨血清nesfatin-1与非酒精性脂肪性肝病（ nonalcoholic fatty liver disease ，NAFLD）的关系。方法选取NAFLD患者及正常对照者各60例，测定BMI、WHR、TG、TC、LDL、HDL、FBG、FIN、nesfatin-1水平，计算HOMA-IR。结果（1） NAFLD患者的BMI、WHR、LDL、TC、TG、FBG、FIN、HOMA-IR均高于正常对照组（P＜0．05），而HDL、nesfatin-1低于正常对照组（P＜0．05）；（2）协方差分析显示，校正年龄、BMI、WHR、TG、TC、FBG、HDL、LDL、FIN、 HOMA-IR等后，两组间nesfatin-1水平的差异具有统计学意义（P＜0．05）；（3）多元逐步回归分析显示，nesfatin-1水平是患NAFLD的危险因素（OR＝1．426，P＜0．01）。结论 NAFLD患者nesfa-tin-1水平明显下降，nesfatin-1可能通过影响摄食行为参与了胰岛素抵抗（ IR）的发生、发展，进而导致NAFLD。
목적：탐토혈청nesfatin-1여비주정성지방성간병（ nonalcoholic fatty liver disease ，NAFLD）적관계。방법선취NAFLD환자급정상대조자각60례，측정BMI、WHR、TG、TC、LDL、HDL、FBG、FIN、nesfatin-1수평，계산HOMA-IR。결과（1） NAFLD환자적BMI、WHR、LDL、TC、TG、FBG、FIN、HOMA-IR균고우정상대조조（P＜0．05），이HDL、nesfatin-1저우정상대조조（P＜0．05）；（2）협방차분석현시，교정년령、BMI、WHR、TG、TC、FBG、HDL、LDL、FIN、 HOMA-IR등후，량조간nesfatin-1수평적차이구유통계학의의（P＜0．05）；（3）다원축보회귀분석현시，nesfatin-1수평시환NAFLD적위험인소（OR＝1．426，P＜0．01）。결론 NAFLD환자nesfa-tin-1수평명현하강，nesfatin-1가능통과영향섭식행위삼여료이도소저항（ IR）적발생、발전，진이도치NAFLD。
Objective To investigate the association between serum nesfatin-1 and nonalcoholic fatty liver disease ( NAFLD) .Methods Sixty patients with NAFLD and 60 normal subjects were selected to measure BMI , WHR, TG, TC, LDL, HDL, FBG, FIN, nesfatin-1 and HOMA-IR.Results (1) BMI, WHR, LDL, TC, TG, FBG, FIN, HO-MA-IR in NAFLD group were higher than those in control group ( P<0 .05 ) , while HDL , nesfatin-1 were lower than those in control group ( P<0.05);(2) According to the analysis of covariance , after adjustment for age , BMI, WHR, TG, TC, FBG, HDL, LDL, FIN, HOMA-IR, difference of nesfatin-1 level between two groups was statistically signifi-cant ( P<0 .05 ); ( 3 ) Multiple stepwise regression analysis suggested that the nesfatin-1 level was a risk factor for NAFLD (OR=1.426, P<0.01).Conclusion The serum nesfatin-1 level is decreased in NAFLD, which may partly contribute to the pathogenesis of insulin resistance in NAFLD .