胃肠病学和肝病学杂志
胃腸病學和肝病學雜誌
위장병학화간병학잡지
CHINESE JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2015年
4期
428-432
,共5页
P53基因密码子72%基因多态性%大肠癌%Meta分析
P53基因密碼子72%基因多態性%大腸癌%Meta分析
P53기인밀마자72%기인다태성%대장암%Meta분석
P53 gene codon 72%Gene polymorphism%Colorectal cancer%Meta-analysis
目的：探讨P53基因密码子72多态性与大肠癌风险的相关性。方法全面检索PubMed、Medline、EMbase、CBM、CNKI、万方和维普等数据库。检索时间从建库至2014年2月，收集 P53基因密码子72多态性与大肠癌易感性的病例对照研究。采用RevMan 5．2软件计算合并效用量OR及其95％CI。结果共纳入25个研究，其中有6753例患者，8562例对照者。 Meta分析发现，在各遗传模型中，隐性模型PP vs AP＋AA中P53基因密码子72多态性与大肠癌发生风险有明显相关性，其余基因模型中P53基因密码子72多态性与大肠癌发生风险无明显相关性。结论在PP vs AP＋AA遗传模型中， P53基因密码子72多态性与大肠癌风险性显著相关。
目的：探討P53基因密碼子72多態性與大腸癌風險的相關性。方法全麵檢索PubMed、Medline、EMbase、CBM、CNKI、萬方和維普等數據庫。檢索時間從建庫至2014年2月，收集 P53基因密碼子72多態性與大腸癌易感性的病例對照研究。採用RevMan 5．2軟件計算閤併效用量OR及其95％CI。結果共納入25箇研究，其中有6753例患者，8562例對照者。 Meta分析髮現，在各遺傳模型中，隱性模型PP vs AP＋AA中P53基因密碼子72多態性與大腸癌髮生風險有明顯相關性，其餘基因模型中P53基因密碼子72多態性與大腸癌髮生風險無明顯相關性。結論在PP vs AP＋AA遺傳模型中， P53基因密碼子72多態性與大腸癌風險性顯著相關。
목적：탐토P53기인밀마자72다태성여대장암풍험적상관성。방법전면검색PubMed、Medline、EMbase、CBM、CNKI、만방화유보등수거고。검색시간종건고지2014년2월，수집 P53기인밀마자72다태성여대장암역감성적병례대조연구。채용RevMan 5．2연건계산합병효용량OR급기95％CI。결과공납입25개연구，기중유6753례환자，8562례대조자。 Meta분석발현，재각유전모형중，은성모형PP vs AP＋AA중P53기인밀마자72다태성여대장암발생풍험유명현상관성，기여기인모형중P53기인밀마자72다태성여대장암발생풍험무명현상관성。결론재PP vs AP＋AA유전모형중， P53기인밀마자72다태성여대장암풍험성현저상관。
Objective To investigate the correlation between P 53 gene codon 72 polymorphism and risk of colorectal cancer (CRC).Methods A comprehensive research was conducted in these databases , such as PubMed, Medline, EMbase, CBM, CNKI, VIP, etc.The retrieval time from building of a database to Feb .2014.All eligible case-control study about the correlation between P 53 gene codon 72 polymorphism and colorectal cancer susceptibility were collected . Pooled odds ratios (OR) with 95%confidence intervals (95%CI) were calculated by the RevMan 5.2 software.Re-sults A total of 25 studies included 6 753 cases of patients and 8 562 cases of controls .Meta-analysis showed that there was significant correlation between the P 53 gene codon 72 polymorphism and colorectal cancer susceptibility in PP vs AP+AA recessive model .There was no significant correlation between P 53 gene codon 72 polymorphism and colorectal cancer susceptibility in the remaining gene models .Conclusion There is significant correlation between the P 53 gene codon 72 polymorphism and colorectal cancer susceptibility in PP vs AP +AA model.
