北京大学学报（医学版）
北京大學學報（醫學版）
북경대학학보（의학판）
JOURNAL OF BEIJING MEDICAL UNIVERSITY(HEALTH SCIENCES)
2015年
2期
352-357
,共6页
王昱%郝燕捷%赵娟%张卓莉
王昱%郝燕捷%趙娟%張卓莉
왕욱%학연첩%조연%장탁리
脂膜炎,红斑狼疮性%红斑狼疮,系统性%皮肤溃疡
脂膜炎,紅斑狼瘡性%紅斑狼瘡,繫統性%皮膚潰瘍
지막염,홍반랑창성%홍반랑창,계통성%피부궤양
Panniculitis,lupus erythematosus%Lupus erythematosus,systemic%Skin ulcers
SUMMARY A 36-year-old woman had an 8-year history of systemic lupus erythematosus (SLE) and was being treated with 10 mg/d of prednisone.She presented with a 6-month history of intermittent fever and multiple painful multi skin erythematous macules in her button, hips and extremities that had slowly en-larged to 8 cm ×4 cm in diameter.The lesions started as painful erythematous macules, which eventually ulcerated and scared.Laboratory tests showed leukopenia, protenuria, positive anti-double strand DNA and hypocomplementemia.Cultures of the bottom ulcer were E.Coli, fugus and Tuberculous mycobacteria were both negative.Biopsy was performed and revealed necrosis of epidermis, thrombus and cellulose de-generation in epidermis with neutrophils karyorrhexis and vasculitis.Her SLE was active, so she was pre-scribed antibiotics for 2 weeks and prednisone was added to 60 mg/d for a month.However her skin ul-cers did not relieve.When prednisone was added to 120 mg/d with combination therapy of cyclophospha-mide and hydroxychloroquine, her skin ulcer cicatrized gradually.
