北京大学学报(医学版)
北京大學學報(醫學版)
북경대학학보(의학판)
JOURNAL OF BEIJING MEDICAL UNIVERSITY(HEALTH SCIENCES)
2015年
2期
349-351
,共3页
肾%淀粉样变性%趋化因子类
腎%澱粉樣變性%趨化因子類
신%정분양변성%추화인자류
Kidney%Amyloidosis%Chemotactic factors
SUMMARY Here we report a case of leukocyte chemotactic factor 2 ( LECT2 )-associated renal amyloi-dosis ( ALect2) in our hospital.A 68-year-old male presented with massive proteinuria, hematuria, and hypertension.The renal function was normal.Light microscopy of the renal biopsy revealed glomeruli, interstitium and arteriole with amorphous pink acellular deposits on hematoxylin and eosin stain.The de-posits were strongly stained for Congo red and presented apple green birefringence viewed with polarized light.Ultrastructural examination revealed nonbranching fibrils ( diameters ranging from 8 nm to 12 nm) distributed in glomerular mesangium, subendothelia and renal interstitium.Immunohistochemistry and immunoelectron microscopy using a polyclonal anti-LECT2 antibody showed that the amyloid deposits and the fibrils were stained positively.ALect2 presented proteinuria,with or without acute/chronic renal dys-function clinically and all compartments of the kidney were involved.