CAJ | 학술논문

目的：探讨妊娠期和哺乳期大鼠正畸牙移动骨改建过程中骨密度和血清骨钙素变化，为临床治疗提供理论依据。方法将75只成年雌性Wistar大鼠随机分成妊娠组、哺乳组、正畸加力未妊娠组、正畸加力妊娠组和正畸加力哺乳组，每组15只，并建立妊娠、哺乳大鼠模型。施加近中向正畸力于5组大鼠的右侧上颌第一磨牙，分别在加力7 d，14 d，21d后取胫骨近端检测骨密度，取静脉血检测骨钙素。结果正畸加力妊娠组和正畸加力哺乳组大鼠第7天，14天，21天胫骨近端骨密度均低于正畸加力未妊娠组，差异有显著性意义（P＜0．05）。正畸加力妊娠组第7天，14天，21天胫骨近端骨密度分别与妊娠组比较，差异无显著性意义（P ＞0．05）。正畸加力哺乳组第7天，14天，21天胫骨近端骨密度分别与哺乳组比较，差异无显著性意义（ P＞0．05）。正畸加力妊娠组和正畸加力哺乳组大鼠第7天，14天，21天血清骨钙素均高于正畸加力未妊娠组，差异有显著性意义（P＜0．05）。正畸加力妊娠组第7天，14天，21天血清骨钙素分别与妊娠组比较，差异无显著性意义（ P＞0．05）。正畸加力哺乳组第14天血清骨钙素高于哺乳组，差异有显著性意义（P＜0．05）。结论相比于未妊娠大鼠，妊娠期大鼠和哺乳期大鼠正畸牙移动过程中胫骨骨密度降低，血清骨钙素升高。
목적：탐토임신기화포유기대서정기아이동골개건과정중골밀도화혈청골개소변화，위림상치료제공이론의거。방법장75지성년자성Wistar대서수궤분성임신조、포유조、정기가력미임신조、정기가력임신조화정기가력포유조，매조15지，병건립임신、포유대서모형。시가근중향정기력우5조대서적우측상합제일마아，분별재가력7 d，14 d，21d후취경골근단검측골밀도，취정맥혈검측골개소。결과정기가력임신조화정기가력포유조대서제7천，14천，21천경골근단골밀도균저우정기가력미임신조，차이유현저성의의（P＜0．05）。정기가력임신조제7천，14천，21천경골근단골밀도분별여임신조비교，차이무현저성의의（P ＞0．05）。정기가력포유조제7천，14천，21천경골근단골밀도분별여포유조비교，차이무현저성의의（ P＞0．05）。정기가력임신조화정기가력포유조대서제7천，14천，21천혈청골개소균고우정기가력미임신조，차이유현저성의의（P＜0．05）。정기가력임신조제7천，14천，21천혈청골개소분별여임신조비교，차이무현저성의의（ P＞0．05）。정기가력포유조제14천혈청골개소고우포유조，차이유현저성의의（P＜0．05）。결론상비우미임신대서，임신기대서화포유기대서정기아이동과정중경골골밀도강저，혈청골개소승고。
Objective To investigate bone mineral density and serum osteocalcin changes during orthodontic tooth move-ment in pregnant and lactation rats.Methods Seventy-five female rats were randomly divided into five groups of fifteen each:pregnant group,lactation group,orthodontic non-pregnant group,orthodontic pregnant group and orthodontic lactation group.To build the pregnant and lactation rats model,and exert medial force on the right side of the maxillary first molar . Each group was divided in 7days,14 days and 21 days,while the same period of tibial bone mineral density ( BMD)and se-rum osteocalcin ( BGP) were detected.Resul ts The BMD of orthodontic pregnant group and orthodontic lactation group was both lower than orthodontic non-pregnant group in 7 days,14 days and 21 days( P<0.05) .The BGP of orthodontic preg-nant group and orthodontic lactation group was both higher than orthodontic non-pregnant group in 7 days,14 days and 21 days(P<0.05).All the difference was statistically significant.Conclusion The BMD decreased and BGP increased in pregnant and lactation rats during orthodontic tooth movement as compared with non-pregnant rats.