CAJ | 학술논문

目的：调查大连市健康体检人群的幽门螺杆菌感染状况，为疾病预防和治疗提供依据。方法采用胶体金双抗夹心层析法检测大连市健康体检人群血清中抗幽门螺杆菌（ Hp ）抗体。分别按性别和年龄分组，统计不同组别Hp抗体阳性率；并与文献报道的不同地区健康体检人群的感染情况做比较。结果大连市健康体检人群Hp抗体的总阳性率为30．4％，男性Hp抗体阳性率为30．0％，女性为30．9％，二者比较差异无显著性意义（ P＞0．05）。21～30岁组人群阳性率最低（19．7％），随着年龄的递增，阳性率也逐渐升高（均P＜0．05），至51～60岁达高峰（33．9％）（均P＜0．05）。在随后的年龄组又逐渐下降，但是51～60、61～70和71～80岁组人群阳性率之间的差异无显著性意义（均P＞0．05）。1～20岁（29．4％）和81～100岁（26．7％）组人群Hp抗体阳性率显著高于21～30岁组人群阳性率。大连地区Hp感染率高于广州，但低于苏州和重庆（均P＜0．05）。结论大连市Hp感染率与其他城市相比处于中等水平。大连地区Hp感染率随年龄增长呈上升趋势，至60岁左右为高峰；随着年龄的进一步增长，其感染率呈下降趋势。
목적：조사대련시건강체검인군적유문라간균감염상황，위질병예방화치료제공의거。방법채용효체금쌍항협심층석법검측대련시건강체검인군혈청중항유문라간균（ Hp ）항체。분별안성별화년령분조，통계불동조별Hp항체양성솔；병여문헌보도적불동지구건강체검인군적감염정황주비교。결과대련시건강체검인군Hp항체적총양성솔위30．4％，남성Hp항체양성솔위30．0％，녀성위30．9％，이자비교차이무현저성의의（ P＞0．05）。21～30세조인군양성솔최저（19．7％），수착년령적체증，양성솔야축점승고（균P＜0．05），지51～60세체고봉（33．9％）（균P＜0．05）。재수후적년령조우축점하강，단시51～60、61～70화71～80세조인군양성솔지간적차이무현저성의의（균P＞0．05）。1～20세（29．4％）화81～100세（26．7％）조인군Hp항체양성솔현저고우21～30세조인군양성솔。대련지구Hp감염솔고우엄주，단저우소주화중경（균P＜0．05）。결론대련시Hp감염솔여기타성시상비처우중등수평。대련지구Hp감염솔수년령증장정상승추세，지60세좌우위고봉；수착년령적진일보증장，기감염솔정하강추세。
Objective To investigate Helicobacter pylori infection in healthy population during regular checkup in Dalian City and provide the basis for prevention and treatment of the disease.Methods Serum Helicobacter pylori ( Hp) antibodies in the population who received regular checkup in Dalian City were d using collaurum double antibody sandwich.Subjects were grouped according to sex and age.The positive rate of Hp antibodies in different groups and different regions were ana-lyzed and compared.Results The positive rate of Hp antibodies was 30% in man and 30.9% in woman with an average positive rate of 30.4%in all population.There was no significant difference between the two groups (P>0.05).The posi-tive rate of Hp antibodies was lowest in the 21-30 years old group (19.7%).The positive rate of Hp antibodies gradually increased in associated age (all P<0.05) and reached a peak level in the 51-60 years old group (33.9%).A gradual decrease was observed afterward.However,no significant differences were found among 51-60,61-70,and 71-80 years old groups (all P>0.05).The positive rates of Hp antibodies in the 1-20 (29.4%) and 81-100 (26.7%) years old groups were higher when compared to 21-30 years old group (all P<0.05).Conclusions Helicobacter pylori infection in healthy population in Dalian City ranks in the medium level when compared to other cities.This infection increases in asso-ciation with age and reaches a peak level at the age around 60.However,the infection gradually decreases in the following age groups.