临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2015年
11期
20-21
,共2页
雷贝拉唑%奥美拉唑%莫沙必利%老年%反流性食管炎
雷貝拉唑%奧美拉唑%莫沙必利%老年%反流性食管炎
뢰패랍서%오미랍서%막사필리%노년%반류성식관염
Rabeprazole%Omeprazole%Mosapride%Old age%Reflux esophagitis
目的：观察雷贝拉唑或奥美拉唑联合莫沙必利（新络纳）治疗老年性反流性食管炎的治疗效果。方法选择食管反流炎患者211例，按照用药方案的不同分为治疗组110例与对照组101例，治疗组口服雷贝拉唑和莫沙必利治疗；对照组口服奥美拉唑和莫沙必利治疗，4周为1个疗程。评价内镜下食管破损黏膜修复和临床症状改善情况及药物不良反应。结果治疗组临床症状改善总有效率96．3％明显高于对照组的85．1％，差异有统计学意义（P＜0．05）。治疗组内镜检查改善情况明显优于对照组，差异有统计学意义（P＜0．05）。治疗组服药后出现腹泻10例（9．0％），减少莫沙必利剂量后腹泻缓解；口干4例，不影响治疗。2组各有4例丙氨酸转氨酶（ALT）轻度增高，停药后恢复正常。结论雷贝拉唑与莫沙必利联合应用治疗胃食管反流病有效率明显高于奥美拉唑联合莫沙必利。
目的：觀察雷貝拉唑或奧美拉唑聯閤莫沙必利（新絡納）治療老年性反流性食管炎的治療效果。方法選擇食管反流炎患者211例，按照用藥方案的不同分為治療組110例與對照組101例，治療組口服雷貝拉唑和莫沙必利治療；對照組口服奧美拉唑和莫沙必利治療，4週為1箇療程。評價內鏡下食管破損黏膜脩複和臨床癥狀改善情況及藥物不良反應。結果治療組臨床癥狀改善總有效率96．3％明顯高于對照組的85．1％，差異有統計學意義（P＜0．05）。治療組內鏡檢查改善情況明顯優于對照組，差異有統計學意義（P＜0．05）。治療組服藥後齣現腹瀉10例（9．0％），減少莫沙必利劑量後腹瀉緩解；口榦4例，不影響治療。2組各有4例丙氨痠轉氨酶（ALT）輕度增高，停藥後恢複正常。結論雷貝拉唑與莫沙必利聯閤應用治療胃食管反流病有效率明顯高于奧美拉唑聯閤莫沙必利。
목적：관찰뢰패랍서혹오미랍서연합막사필리（신락납）치료노년성반류성식관염적치료효과。방법선택식관반류염환자211례，안조용약방안적불동분위치료조110례여대조조101례，치료조구복뢰패랍서화막사필리치료；대조조구복오미랍서화막사필리치료，4주위1개료정。평개내경하식관파손점막수복화림상증상개선정황급약물불량반응。결과치료조림상증상개선총유효솔96．3％명현고우대조조적85．1％，차이유통계학의의（P＜0．05）。치료조내경검사개선정황명현우우대조조，차이유통계학의의（P＜0．05）。치료조복약후출현복사10례（9．0％），감소막사필리제량후복사완해；구간4례，불영향치료。2조각유4례병안산전안매（ALT）경도증고，정약후회복정상。결론뢰패랍서여막사필리연합응용치료위식관반류병유효솔명현고우오미랍서연합막사필리。
Objective To observe the effect of rabeprazole ,omeprazole combined with mosapride in the treatment of senile reflux esophagitis .Methods 211 cases of patients with reflux esophagitis were selected and randomly divided into treat -ment group (110 cases) and control group (101 cases) according to the different therapeutic schemes .The treatment group was treated with rabeprazole and mosapride ,while the control group was treated with omeprazole and mosapride .4 weeks as a course of treatment.The endoscopic esophageal mucosal damage repair degree ,the improvement of clinical symptoms and ad-verse effects of drugs were evaluated .Results The total effective rate was 96.3% about the clinical symptoms in treatment group,which was higher than 85.1%in the control group,the difference was statistically significant (P<0.05).The improve-ment condition of esophageal mucosa damage in the treatment group was significantly better than that of the control group ,the difference was statistically significant (P<0.05).10 cases of the treatment group had diarrhea after medication (9.1%).Af-ter reducing mosapride dose ,the diarrhea symptom of patients was alleviated .4 cases of dry mouth ,it did not affect the treat-ment.There were 4 cases with mild elevated alanine aminotransferase (ALT) in each group,they returned to normal after stop-ping drug.Conclusion The effect of combined application of rabeprazole and mosapride is significantly higher than ome -prazole in the treatment of gastroesophageal reflux disease .
