CAJ | 학술논문

目的：观察盐酸羟考酮用于老年患者术后镇痛的效果及安全性，为临床用药提供依据。方法选取医院收治入院的老年手术患者80例为研究资料，将其随机分为2组（ A组和B组）各40例，患者经全麻诱导、气管插管后行机械通气下完成手术。 A组给予盐酸羟考酮30mg＋托烷司琼10mg，B组给予盐酸羟考酮30mg＋氟比洛芬酯150mg＋托烷司琼10mg；记录观察苏醒后（T0）、2h（T1）、4h（T2）、12h（T3）、24h（T4）的VAS评分和Ramsay镇静评分及各时点PCA泵按压次数、不良反应发生率。结果 A组和B组都可以到达较好的术后镇痛效果。与B组比较，T0、T1、T2时A组VAS评分明显升高（P＜0．05）。 B组Ramsay镇静评分明显升高（P＜0．05）。 A组PCA实际、有效按压次数明显增多（ P＜0．05）。差异均有统计学意义。结论盐酸羟考酮用于老年患者术后镇痛是安全有效的，不良反应少，适合临床应用。
목적：관찰염산간고동용우노년환자술후진통적효과급안전성，위림상용약제공의거。방법선취의원수치입원적노년수술환자80례위연구자료，장기수궤분위2조（ A조화B조）각40례，환자경전마유도、기관삽관후행궤계통기하완성수술。 A조급여염산간고동30mg＋탁완사경10mg，B조급여염산간고동30mg＋불비락분지150mg＋탁완사경10mg；기록관찰소성후（T0）、2h（T1）、4h（T2）、12h（T3）、24h（T4）적VAS평분화Ramsay진정평분급각시점PCA빙안압차수、불량반응발생솔。결과 A조화B조도가이도체교호적술후진통효과。여B조비교，T0、T1、T2시A조VAS평분명현승고（P＜0．05）。 B조Ramsay진정평분명현승고（P＜0．05）。 A조PCA실제、유효안압차수명현증다（ P＜0．05）。차이균유통계학의의。결론염산간고동용우노년환자술후진통시안전유효적，불량반응소，괄합림상응용。
Objective To observe the effect and safety of oxycodone hydrochloride used in elderly patients for postop -erative analgesia ,in order to provide a basis for clinical medicine .Methods 80 research data of elderly surgical patients were selected in our hospital .All the patients were randomly divided into 2 groups ( group A and group B ) .The operation was com-pleted under mechanical ventilation after general anesthesia induction and endotracheal intubation .According to different group give different patient controlled intravenous analgesia ( PCIA) drug.Group A:oxycodone hydrochloride 30mg +tropisetron 10mg.Group B:oxycodone hydrochloride 30mg+flurbiprofen 150mg+tropisetron 10mg.VAS and Ramsay score,pressure times of PCA pump,and the incidence of adverse events were recorded in (T0),2h(T1),4h(T2),12h(T3),24h(T4) after recover-y.Results Group A and group B can achieve effective analgesia .Compared with group B,the VAS in group A was signifi-cantly higher at T0,T1,T2(P<0.05).The Ramsay score in group B was significantly increased (P<0.05).The real and ef-fective press times of PCA pump was significantly increased in group A ,the difference was statistically significant ( P<0.05 ) . Conclusion The oxycodone hydrochloride used in elderly patients for postoperative analgesia is safe ,effective,with fewer ad-verse events.So it is suitable for clinical use .