CAJ | 학술논문

矿物药是中国传统药学中不可缺少的重要组成部分。禹余粮作为常用矿物药之一，在临床上有着广泛的使用和确切的疗效，长期用于治疗久泻，便血和崩漏带下。由于禹余粮原矿物成因复杂，通常由多种矿物组成，且组成比例不一，导致目前市场矿物药禹余粮品种来源较混乱，质量参差不齐，真假难以分辨。2010版《中国药典》所收载矿物药禹余粮的质量控制标准仅有简单的性状和铁盐的化学鉴别项目，不能很好的控制禹余粮的质量。通过FTIR方法建立矿物药禹余粮FTIR指纹图谱，并对禹余粮炮制前后及伪品FT‐IR图谱进行了比较分析。对不同产地和批次18份禹余粮样品进行分析，FTIR指纹图谱相似度评价以计算共有峰透光率的夹角余弦值获得。结果显示，禹余粮样品的FTIR指纹图谱相似度、相关系数均大于0.90；禹余粮生品、炮制品、伪品红外图谱存在较大差异。阐述了利用FT IR指纹图谱研究禹余粮的成分特征，能够快速、简便地区分真伪及炮制前后的禹余粮样品。禹余粮FT IR指纹图谱的建立为矿物药禹余粮质量评价提供了新方法，为《中国药典》禹余粮药材质量标准的完善提供了依据。
광물약시중국전통약학중불가결소적중요조성부분。우여량작위상용광물약지일，재림상상유착엄범적사용화학절적료효，장기용우치료구사，편혈화붕루대하。유우우여량원광물성인복잡，통상유다충광물조성，차조성비례불일，도치목전시장광물약우여량품충래원교혼란，질량삼차불제，진가난이분변。2010판《중국약전》소수재광물약우여량적질량공제표준부유간단적성상화철염적화학감별항목，불능흔호적공제우여량적질량。통과FTIR방법건립광물약우여량FTIR지문도보，병대우여량포제전후급위품FT‐IR도보진행료비교분석。대불동산지화비차18빈우여량양품진행분석，FTIR지문도보상사도평개이계산공유봉투광솔적협각여현치획득。결과현시，우여량양품적FTIR지문도보상사도、상관계수균대우0.90；우여량생품、포제품、위품홍외도보존재교대차이。천술료이용FT IR지문도보연구우여량적성분특정，능구쾌속、간편지구분진위급포제전후적우여량양품。우여량FT IR지문도보적건립위광물약우여량질량평개제공료신방법，위《중국약전》우여량약재질량표준적완선제공료의거。
In the present paper ,the fingerprint of Limonitum (a mineral Chinese medicine) by FTIR was es‐tablished ,and the spectrograms among crude samples ,processed one and the adulterant sample were compared . Eighteen batches of Limonitum samples from different production areas were analyzed and the angle cosine val‐ue of transmittance (% )of common peaks was calculated to get the similarity of the FTIR fingerprints .The re‐sult showed that the similarities and the coefficients of the samples were all more than 0.90 .The processed samples revealed significant differences compared with the crude one .This study analyzed the composition characteristics of Limonitum in FTIR fingerprint ,and it was simple and fast to distinguish the crude ,pro‐cessed and the counterfeit samples .The FTIR fingerprints provide a new method for evaluating the quality of Limonitum .