CAJ | 학술논문

背景：医用聚乙二醇小檗碱是一种抗组织粘连生物材料，具有抗炎作用，可预防瘢痕组织形成，减轻局部炎症反应。目的：根据医用聚乙二醇小檗碱的作用机制及特点，观察其肩关节注射修复肩峰下撞击综合征的临床疗效。方法：纳入40例Ⅰ、Ⅱ期肩峰下撞击综合征患者，根据自愿的原则进入生物材料治疗组(n=20)和保守治疗组(n=20)。保守治疗组进行复方倍他米松混合盐酸利多卡因肩峰下间隙封闭治疗1次后，口服塞来昔布200 mg/次，2次/d，药物治疗1周；生物材料治疗组采用3 mL医用聚乙二醇小檗碱肩关节注射治疗1次。门诊随访两组目测类比评分、肩关节活动度及美国肩肘外科学会肩关节评分。结果与结论：两组治疗后的目测类比评分、肩关节活动度及美国肩肘外科学会肩关节评分均较治疗前明显改善(P <0.05)，并且生物材料治疗组修复后2周、4周、3个月、6个月的目测类比评分、肩关节活动度及美国肩肘外科学会肩关节评分均较保守治疗组改善更明显(P <0.001)。说明医用聚乙二醇小檗碱肩关节腔内注射修复肩峰下撞击综合征可有效缓解肩部疼痛，提高肩关节活动度，促进肩关节功能恢复。
배경：의용취을이순소벽감시일충항조직점련생물재료，구유항염작용，가예방반흔조직형성，감경국부염증반응。목적：근거의용취을이순소벽감적작용궤제급특점，관찰기견관절주사수복견봉하당격종합정적림상료효。방법：납입40례Ⅰ、Ⅱ기견봉하당격종합정환자，근거자원적원칙진입생물재료치료조(n=20)화보수치료조(n=20)。보수치료조진행복방배타미송혼합염산리다잡인견봉하간극봉폐치료1차후，구복새래석포200 mg/차，2차/d，약물치료1주；생물재료치료조채용3 mL의용취을이순소벽감견관절주사치료1차。문진수방량조목측류비평분、견관절활동도급미국견주외과학회견관절평분。결과여결론：량조치료후적목측류비평분、견관절활동도급미국견주외과학회견관절평분균교치료전명현개선(P <0.05)，병차생물재료치료조수복후2주、4주、3개월、6개월적목측류비평분、견관절활동도급미국견주외과학회견관절평분균교보수치료조개선경명현(P <0.001)。설명의용취을이순소벽감견관절강내주사수복견봉하당격종합정가유효완해견부동통，제고견관절활동도，촉진견관절공능회복。
BACKGROUND:Medical polyethylene glycol berberine is a biomaterial against tissue adhesion, with anti-inflammatory effects, which can prevent scar formation and reduce local inflammation. OBJECTIVE:To observe the clinical efficacy of medical polyethylene glycol berberinevia shoulder joint injections on subacromial impingement syndrome. METHODS:Forty patients with subacromial impingement syndrome I, II were voluntarily divided into two groups: biomaterial group (n=20), single intra-articular injection of 3 mL medical polyethylene glycol berberine; conservative treatment group (n=20), single subacromial space closed treatment of betamethasone combined with lidocaine hydrochloride folowed by oral administration of celecoxib 200 mg once, twice a day, totaly for 1 week. Patients were folowed up clinicaly for visual analog scale scores, range of motion of the shoulder and the American Shoulder and Elbow Surgeons scores. RESULTS AND CONCLUSION:Both of two groups had a great improvement in visual analog scale scores, range of motion of the shoulder and the American Shoulder and Elbow Surgeons scores after treatment (P< 0.05), and these scores were improved more significantly in the biomaterial group than the conservative treatment group at 2 weeks, 4 weeks, 3 months, 6 months after treatment (P < 0.001). These findings indicate that the intra-articular injection of medical polyethylene glycol berberine for subacromial impingement syndrome can effectively aleviate shoulder pain, improve shoulder mobility, and promote functional recovery of the shoulder.