中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
12期
1884-1888
,共5页
生物材料%材料相容性%锚定技术%支架%球囊%钢丝%冠状动脉%血管成形
生物材料%材料相容性%錨定技術%支架%毬囊%鋼絲%冠狀動脈%血管成形
생물재료%재료상용성%묘정기술%지가%구낭%강사%관상동맥%혈관성형
Coronary Vessels%Angioplasty,Baloon,Coronary%Coronary Artery Disease
背景：边支球囊锚定和远端钢丝锚定是提高冠状动脉内支架通过到位率的有效办法，目前国内尚无比较上述两种锚定方法在提高支架通过成功率方面的研究。目的：比较边支球囊锚定和远端钢丝锚定在提高冠状动脉介入治疗药物洗脱支架通过困难方面的临床效果。方法：纳入87例冠状动脉介入治疗过程中药物洗脱支架通过困难病例，随机分2组治疗，其中46例采用边支球囊锚定方法提高支架通过到位率，41例采用远端钢丝锚定方法提高支架通过到位率。对比两组患者支架置入成功率，以及支架置入12个月内的支架材料生物相容性问题，包括主要不良心脏反应、再发心绞痛、支架再狭窄和晚期管腔丢失等。结果与结论：远端钢丝锚定组药物洗脱支架置入成功率明显高于边支球囊锚定组(83%，61%，P <0.05)，两组患者药物洗脱支架置入过程中并发症及支架置入12个月内的主要不良心脏反应、再发心绞痛、支架再狭窄和晚期管腔丢失结果比较差异无显著性意义(P >0.05)。说明远端钢丝球囊锚定方法在不影响支架材料生物相容性的情况下，更有利于提高冠状动脉支架通过率。
揹景：邊支毬囊錨定和遠耑鋼絲錨定是提高冠狀動脈內支架通過到位率的有效辦法，目前國內尚無比較上述兩種錨定方法在提高支架通過成功率方麵的研究。目的：比較邊支毬囊錨定和遠耑鋼絲錨定在提高冠狀動脈介入治療藥物洗脫支架通過睏難方麵的臨床效果。方法：納入87例冠狀動脈介入治療過程中藥物洗脫支架通過睏難病例，隨機分2組治療，其中46例採用邊支毬囊錨定方法提高支架通過到位率，41例採用遠耑鋼絲錨定方法提高支架通過到位率。對比兩組患者支架置入成功率，以及支架置入12箇月內的支架材料生物相容性問題，包括主要不良心髒反應、再髮心絞痛、支架再狹窄和晚期管腔丟失等。結果與結論：遠耑鋼絲錨定組藥物洗脫支架置入成功率明顯高于邊支毬囊錨定組(83%，61%，P <0.05)，兩組患者藥物洗脫支架置入過程中併髮癥及支架置入12箇月內的主要不良心髒反應、再髮心絞痛、支架再狹窄和晚期管腔丟失結果比較差異無顯著性意義(P >0.05)。說明遠耑鋼絲毬囊錨定方法在不影響支架材料生物相容性的情況下，更有利于提高冠狀動脈支架通過率。
배경：변지구낭묘정화원단강사묘정시제고관상동맥내지가통과도위솔적유효판법，목전국내상무비교상술량충묘정방법재제고지가통과성공솔방면적연구。목적：비교변지구낭묘정화원단강사묘정재제고관상동맥개입치료약물세탈지가통과곤난방면적림상효과。방법：납입87례관상동맥개입치료과정중약물세탈지가통과곤난병례，수궤분2조치료，기중46례채용변지구낭묘정방법제고지가통과도위솔，41례채용원단강사묘정방법제고지가통과도위솔。대비량조환자지가치입성공솔，이급지가치입12개월내적지가재료생물상용성문제，포괄주요불양심장반응、재발심교통、지가재협착화만기관강주실등。결과여결론：원단강사묘정조약물세탈지가치입성공솔명현고우변지구낭묘정조(83%，61%，P <0.05)，량조환자약물세탈지가치입과정중병발증급지가치입12개월내적주요불양심장반응、재발심교통、지가재협착화만기관강주실결과비교차이무현저성의의(P >0.05)。설명원단강사구낭묘정방법재불영향지가재료생물상용성적정황하，경유리우제고관상동맥지가통과솔。
BACKGROUND:Both distal-wire anchoring technique and branch-baloon anchoring technique are the effective ways of improving the ability to deliver stents to the target lesions. There is no study addressing the comparison of these two techniques in the successful stent delivery to stenosis lesions at present. OBJECTIVE: To evaluate the clinical effect of distal-wire anchoring techniqueversus branch-baloon anchoring technique in delivering stents to complex lesions. METHODS:We retrospectively analyzed the clinical data of 87 cases of difficultly delivering stents in the process of coronary intervention, in which 46 cases were treated with branch-baloon anchoring technique and 41 cases treated with distal-wire anchoring technique. Then, stent implantation rate, major adverse cardiac reactions and recurrence of angina pectoris within 12 months, and late lumen loss, restenosis after stent implantation were compared between the two groups. RESULTS AND CONCLUSION:The successful stenting rate of distal-wire anchoring technique group was significantly higher than that of branch-baloon anchoring technique group (83%vs. 61%,P< 0.05). There were no significant differences between two groups patients in complications during stenting, major adverse cardiac reactions and recurrence of angina pectoris within 12 months, and late lumen loss, restenosis after stent implantation. The study indicates that the distal-wire anchoring technique is of safety and effectiveness method for dealing with inability to deliver stents to the target lesions.
