中国卫生标准管理
中國衛生標準管理
중국위생표준관리
CHINA HEALTH STANDARD MANAGEMENT
2015年
7期
228-229
,共2页
替加环素%合成工艺%米诺环素
替加環素%閤成工藝%米諾環素
체가배소%합성공예%미낙배소
Tigecycline%Synthesis process%Minocycline
目的：探析并改进替加环素的合成工艺，为提高其应用价值提供依据。方法以米诺环素作为原料，经过硝化、还原、成盐酸盐、亲核取代反应等合成制得替加环素。结果替加环素总收率为42.2%，纯度为99.9%，差向异构体＜0.1%。结论本研究优化了替加环素合成工艺，且得到高质量产品，为工业化生产提供了重要依据。
目的：探析併改進替加環素的閤成工藝，為提高其應用價值提供依據。方法以米諾環素作為原料，經過硝化、還原、成鹽痠鹽、親覈取代反應等閤成製得替加環素。結果替加環素總收率為42.2%，純度為99.9%，差嚮異構體＜0.1%。結論本研究優化瞭替加環素閤成工藝，且得到高質量產品，為工業化生產提供瞭重要依據。
목적：탐석병개진체가배소적합성공예，위제고기응용개치제공의거。방법이미낙배소작위원료，경과초화、환원、성염산염、친핵취대반응등합성제득체가배소。결과체가배소총수솔위42.2%，순도위99.9%，차향이구체＜0.1%。결론본연구우화료체가배소합성공예，차득도고질양산품，위공업화생산제공료중요의거。
Objective To analyze and improve the synthetic process of Tigecycline and provide the basis for enhancing its application value. Methods With Minocycline as raw material,Tigecycline was synthetized through nitration,deoxidation,hydrochloride synthesis,nucleophilic substitution,etc. Results The overal yield of Tigecycline was 42.2%,its purity was 99.9%,and its epimer was less than 0.1%. Conclusion This research optimizes the synthetic process of Tigecycline so as to obtain high-quality products,providing an important basis for the industrialized production of Tigecycline.
