CAJ | 학술논문

目的：探讨健康管理防治高同型半胱氨酸血症的价值。方法将健康体检中MTHFR C677T基因多态性伴HHcy、血脂异常增高者作为研究对象，随机分成对照组和观察组。两组在规范叶酸、维生素B6强化治疗的基础上，又对观察组实施个性化健康促进干预措施。结果对照组连续6个月药品强化治疗后，Hcy、血脂水平未明显下降，差异无统计学意义(P>0.05)。连续12个月药品强化治疗后，Hcy及血脂水平明显下降，差异有统计学意义(P<0.001,P<0.05)。观察组在个性化健康促进干预6个月、12个月后，Hcy及血脂水平显著降低，差异有统计学意义(P<0.001，P<0.001)。结论健康管理可显著降低MTHFR C677T基因多态性伴HHcy、血脂异常目标人群Hcy、血脂水平，提高服药依从性，这将有助于控制高危因素，预防脑血管疾病的发生。
목적：탐토건강관리방치고동형반광안산혈증적개치。방법장건강체검중MTHFR C677T기인다태성반HHcy、혈지이상증고자작위연구대상，수궤분성대조조화관찰조。량조재규범협산、유생소B6강화치료적기출상，우대관찰조실시개성화건강촉진간예조시。결과대조조련속6개월약품강화치료후，Hcy、혈지수평미명현하강，차이무통계학의의(P>0.05)。련속12개월약품강화치료후，Hcy급혈지수평명현하강，차이유통계학의의(P<0.001,P<0.05)。관찰조재개성화건강촉진간예6개월、12개월후，Hcy급혈지수평현저강저，차이유통계학의의(P<0.001，P<0.001)。결론건강관리가현저강저MTHFR C677T기인다태성반HHcy、혈지이상목표인군Hcy、혈지수평，제고복약의종성，저장유조우공제고위인소，예방뇌혈관질병적발생。
Objective To explore the value of health management in prevention and treatment of hyperhomocysteinemia.Methods The research object was people with MTHFR C677T gene polymorphism, HHcy and abnormal blood lipid had been screened in physical examination who were divided into a control group and a observation group. Two groups took specification of folic acid, vitamin B6 treatment, observation group to implement personalized health promotion interventions.Results Hcy and lipid of the control group was not signiifcantly lower in 6 months after drug treatment. There was no statistically signiifcant difference (P>0.05). Hcy and lipid of the control group was signiifcantly lower in 12 months after drug treatment.There was statistically signiifcant difference (P<0.001,P<0.05). Hcy and lipid of the observation group was signiifcantly lower in personalized health promotion intervention 6 months and 12 months later.There was statistically significant difference (P<0.001,P<0.001).Conclusion Health management can reduce the target population Hcy and lipid level, increase medication compliance, this will help to control the risk factors, prevent the happening of the cerebrovascular disease.