中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2015年
11期
102-103
,共2页
方汉刚%陈建新%乔健国%柴国清%韩劲松
方漢剛%陳建新%喬健國%柴國清%韓勁鬆
방한강%진건신%교건국%시국청%한경송
食管癌%血清%P53蛋白%临床意义
食管癌%血清%P53蛋白%臨床意義
식관암%혈청%P53단백%림상의의
Esophagus cancer%Serum%P53 protein%Clinical significance
目的：测定食管癌患者血清中P53蛋白含量，分析其临床意义。方法：2010年9月-2014年8月收治食管疾病患者86例，根据病理组织学诊断结果，分为食管炎组和食管癌组，测定两组血清中P53蛋白含量，对比分析两组的差异性。食管癌组给予综合治疗2个月后，复查血清中P53蛋白含量，对比分析治疗前后的差异性。结合临床病理特征分析食管癌组血清中P53蛋白含量的临床意义。结果：外周血清中P53蛋白含量，食管炎组(0.726±0.531)μg/mL，食管癌组治疗前(2.381±1.412)μg/mL，治疗后(1.096±0.689)μg/mL。两组对比差异有统计学意义。食管癌治疗前后对比差异有统计学意义(P＜0.05)。食管癌患者血清中P53蛋白含量与细胞分化、局部浸润、淋巴结转移相关。结论：食管癌患者血清中P53蛋白含量对食管癌的诊断及预后有一定的指导意义。
目的：測定食管癌患者血清中P53蛋白含量，分析其臨床意義。方法：2010年9月-2014年8月收治食管疾病患者86例，根據病理組織學診斷結果，分為食管炎組和食管癌組，測定兩組血清中P53蛋白含量，對比分析兩組的差異性。食管癌組給予綜閤治療2箇月後，複查血清中P53蛋白含量，對比分析治療前後的差異性。結閤臨床病理特徵分析食管癌組血清中P53蛋白含量的臨床意義。結果：外週血清中P53蛋白含量，食管炎組(0.726±0.531)μg/mL，食管癌組治療前(2.381±1.412)μg/mL，治療後(1.096±0.689)μg/mL。兩組對比差異有統計學意義。食管癌治療前後對比差異有統計學意義(P＜0.05)。食管癌患者血清中P53蛋白含量與細胞分化、跼部浸潤、淋巴結轉移相關。結論：食管癌患者血清中P53蛋白含量對食管癌的診斷及預後有一定的指導意義。
목적：측정식관암환자혈청중P53단백함량，분석기림상의의。방법：2010년9월-2014년8월수치식관질병환자86례，근거병리조직학진단결과，분위식관염조화식관암조，측정량조혈청중P53단백함량，대비분석량조적차이성。식관암조급여종합치료2개월후，복사혈청중P53단백함량，대비분석치료전후적차이성。결합림상병리특정분석식관암조혈청중P53단백함량적림상의의。결과：외주혈청중P53단백함량，식관염조(0.726±0.531)μg/mL，식관암조치료전(2.381±1.412)μg/mL，치료후(1.096±0.689)μg/mL。량조대비차이유통계학의의。식관암치료전후대비차이유통계학의의(P＜0.05)。식관암환자혈청중P53단백함량여세포분화、국부침윤、림파결전이상관。결론：식관암환자혈청중P53단백함량대식관암적진단급예후유일정적지도의의。
Objective:To measure the serum P53 protein content of patients with esophageal cancer,to analyze its clinical significance.Methods:86 patients with esophageal disease were selected from September 2010 to August 2014.According to the pathological diagnosis result,the patients were divided into the esophagitis group and the esophageal cancer group.The serum P53 protein contents of two groups were measured,the difference of two groups was analyzed.The esophageal cancer group was given comprehensive treatment,after 2 months,the serum P53 protein content was counterchecked,the differences between before and after treatment were analyzed.The clinical significance of serum P53 protein content in the esophageal cancer group was analyzed under combined with clinical pathological characteristics.Results:P53 protein content in the peripheral serum:the esophagitis group was (0.726 ± 0.531)μg/mL,the esophageal cancer group before treatment was (2.381 ± 1.412)μg/mL,after treatment was (1.096 ± 0.689)μg/mL.The two groups comparison had statistical significant difference.Before and after treatment of esophageal cancer were compared with statistical significant difference(P<0.05).The serum P53 protein content of patients with esophageal carcinoma had correlation with cell differentiation,local infiltration, lymph node metastasis.Conclusion:The serum P53 protein content of patients with esophagus cancer has certain guiding significance for diagnosis and prognosis of esophagus cancer.
