CAJ | 학술논문

目的：通过检测血清胱抑素C（ CysC）水平，研究其在慢性心力衰竭（ CHF）发生发展中的变化，评估心力衰竭的预后。方法：选取2012年12月—2014年5月住院的心力衰竭患者650例及正常对照组100例，依据纽约心脏病协会（ NYHA）心功能分级标准，将心力衰竭患者的心功能分为Ⅱ~Ⅳ级，其中心功能Ⅱ级组128例，Ⅲ级组185例和Ⅳ级组337例。结果：CysC水平随心功能分级的升高而升高；CysC与射血分数呈负相关；CysC水平与左室舒张末期内径大小呈正相关。结论：CysC水平与CHF具有相关性，参与了心力衰竭的发生发展，可以间接反映心力衰竭的严重程度。
목적：통과검측혈청광억소C（ CysC）수평，연구기재만성심력쇠갈（ CHF）발생발전중적변화，평고심력쇠갈적예후。방법：선취2012년12월—2014년5월주원적심력쇠갈환자650례급정상대조조100례，의거뉴약심장병협회（ NYHA）심공능분급표준，장심력쇠갈환자적심공능분위Ⅱ~Ⅳ급，기중심공능Ⅱ급조128례，Ⅲ급조185례화Ⅳ급조337례。결과：CysC수평수심공능분급적승고이승고；CysC여사혈분수정부상관；CysC수평여좌실서장말기내경대소정정상관。결론：CysC수평여CHF구유상관성，삼여료심력쇠갈적발생발전，가이간접반영심력쇠갈적엄중정도。
Objective:To study the role of CystainC( CysC)in the development of chronic heart failure( CHF)by chec-king the serum CysC with CHF,to assess the prognosis of heart failure. Methods:A total of 650 patients with heart failure from December 2012 to May 2014 in hospital were chosen. According to the New York heart association( NYHA)cardiac function classification standard,patients were divided into three groups:128 cases of NYHA Ⅱ,185 cases of NYHA Ⅲ,337 cases of NYHAⅣ,with 100 patients as control subjects. Results:The levels of serum CysC increased with the higher function of NYHA hert functional classification. The level of CysC had negative correlation with the ejection fraction. The CysC level and left ven-tricular end—diastolic diameter size were positively correlated. Conclusion:The CysC level associated with CHF,participated in the development,the occurrence of heart failure can indirectly reflect the severity of heart failure.