CAJ | 학술논문

目的：探讨皮下注射磺达肝癸钠治疗ST段抬高型心肌梗死的可行性。方法：2012年3月-2014年3月收治ST段抬高型心肌梗死患者60例，依据随机数字表法分为研究组和对照组，每组30例。对照组给予皮下注射那曲肝素治疗，研究组给予皮下注射磺达肝癸钠治疗，然后对两组患者心血管事件及出血发生情况进行统计分析。结果：研究组患者治疗后1周轻度出血发生率(0)明显比对照组[13.3%(4/30)]低(P＜0.05)，治疗后1个月严重出血和轻度出血发生率(0、0)均明显比对照组[13.3%(4/30)、16.7%(5/30)]低(P＜0.05)；治疗后1周、1个月两组患者的心血管事件发生率之间的差异均无统计学意义(P＞0.05)。结论：皮下注射磺达肝癸钠治疗ST段抬高型心肌梗死安全可行，值得推广。
목적：탐토피하주사광체간계납치료ST단태고형심기경사적가행성。방법：2012년3월-2014년3월수치ST단태고형심기경사환자60례，의거수궤수자표법분위연구조화대조조，매조30례。대조조급여피하주사나곡간소치료，연구조급여피하주사광체간계납치료，연후대량조환자심혈관사건급출혈발생정황진행통계분석。결과：연구조환자치료후1주경도출혈발생솔(0)명현비대조조[13.3%(4/30)]저(P＜0.05)，치료후1개월엄중출혈화경도출혈발생솔(0、0)균명현비대조조[13.3%(4/30)、16.7%(5/30)]저(P＜0.05)；치료후1주、1개월량조환자적심혈관사건발생솔지간적차이균무통계학의의(P＞0.05)。결론：피하주사광체간계납치료ST단태고형심기경사안전가행，치득추엄。
Objective:To explore the feasibility of subcutaneous injection of fondaparinux for ST-segment elevation myocardial infarction.Methods:60 patients with ST-segment elevation myocardial infarction were selected from March 2012 to March 2014. They were divided into the study group and the control group with 30 cases in each according to the random number table method. The control group was given subcutaneous injection of nadroparin treatment.The study group was given subcutaneous injection of fondaparinux treatment.The cardiovascular events and bleeding occurrence condition of patients in two groups were collected and analyzed.Results:At 1 week after treatment,the incidence rate of mild bleeding(0) of the study group was lower than 13.3%(4/30) of the control group.At 1 month after treatment,the incidence rate of severe bleeding and mild bleeding(0,0) were significantly lower than 13.3%(4/30)、16.7%(5/30) of the control group.The differences between the incidence rates of cardiovascular events in two groups at 1 week and 1 month after treatment were not significant(P>0.05).Conclusion:The subcutaneous injection of fondaparinux in the treatment of ST-segment elevation myocardial infarction is safety and feasible,it is worthy of promotion.