CAJ | 학술논문

背景：碱性成纤维细胞生长因子具有促进新生血管生成和结缔组织再生等多种生物学作用，但其在体内可被快速降解，而纤维蛋白胶作为载体则可通过缓释作用避免碱性成纤维细胞生长因子在体内的快速降解，从而更好的发挥其生物学作用，但目前二者的具体运用方式尚处于研究阶段。目的：对碱性成纤维细胞生长因子及纤维蛋白胶在骨科领域的运用研究进展进行综述。方法：由第一作者用计算机检索2000至2014年中国期刊全文数据库和Medline数据库相关文献，总结分析碱性成纤维细胞生长因子及纤维蛋白胶在骨科的运用情况。结果与结论：最终纳入的64篇文献的整理分析结果提示，碱性成纤维细胞生长因子可以通过纤维蛋白胶的载体作用，达到促进促进创伤愈合与组织修复的目的，但多数研究尚处于实验阶段，其在骨科领域的临床应用还需要进一步的探索。
배경：감성성섬유세포생장인자구유촉진신생혈관생성화결체조직재생등다충생물학작용，단기재체내가피쾌속강해，이섬유단백효작위재체칙가통과완석작용피면감성성섬유세포생장인자재체내적쾌속강해，종이경호적발휘기생물학작용，단목전이자적구체운용방식상처우연구계단。목적：대감성성섬유세포생장인자급섬유단백효재골과영역적운용연구진전진행종술。방법：유제일작자용계산궤검색2000지2014년중국기간전문수거고화Medline수거고상관문헌，총결분석감성성섬유세포생장인자급섬유단백효재골과적운용정황。결과여결론：최종납입적64편문헌적정리분석결과제시，감성성섬유세포생장인자가이통과섬유단백효적재체작용，체도촉진촉진창상유합여조직수복적목적，단다수연구상처우실험계단，기재골과영역적림상응용환수요진일보적탐색。
BACKGROUND:Basic fibroblast growth factor can promote angiogenesis and connective tissue regeneration, but it can be degraded rapidly in vivo. Fibrin glue as a carrier can play a slow-release effect against the rapid degradation of basic fibroblast growth factor, so as to better play the biological role of basic fibroblast growth factor. But at present, the concrete application of them is stil in the research stage. OBJECTIVE:To review the research progress of the application of basic fibroblast growth factor and fibrin glue in orthopedics. METHODS:The recent literature concerning the application of basic fibroblast growth factor and fibrin glue in orthopedics was extensively reviewed by the first author through a computer-based retrieval of CNKI and Medline databases (2000-2014). RESULTS AND CONCLUSION:Finaly 64 articles were included in result analysis. Basic fibroblast growth factor can promote wound healing and tissue repair with the fibrin glue used as a carrier, but most studies are stil in the experimental stage and its clinical application needs further study.