中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
12期
1938-1942
,共5页
生物材料%骨生物材料%组织工程骨%支架材料%生物降解%植骨稳定性%国家自然科学基金
生物材料%骨生物材料%組織工程骨%支架材料%生物降解%植骨穩定性%國傢自然科學基金
생물재료%골생물재료%조직공정골%지가재료%생물강해%식골은정성%국가자연과학기금
Tissue Engineering%Stents%Bone Transplantation
背景:支架材料是组织工程骨重要的组成部分,理想材料的生物降解速度应与新骨替代生成速度一致,最终材料完全降解被新骨取代,以达到长期稳定的目的。目的:综述现有不同类型支架材料的降解及其与新骨形成的关系。方法:由第一作者从PubMed数据库及CNKI数据库中,以“tissue engineering bone,composite scaffold, scaffold degradation;组织工程骨,支架材料,生物降解”为主题词检索1996年1月至2013年12月间发表的文献,选择与支架材料降解及其与新骨形成关系的相关文献。结果与结论:目前已有多种有机、无机及有机-无机复合材料作为支架材料,近年来重点是对无机材料及有机-无机材料复合物开展研究。体内外实验结果表明,各类材料具备不同的特性且各有优劣。有机材料降解速率相对较慢,无机材料虽能完全降解,但机械性能不够,对于复合材料仍需要开展进一步的动物实验和临床研究。
揹景:支架材料是組織工程骨重要的組成部分,理想材料的生物降解速度應與新骨替代生成速度一緻,最終材料完全降解被新骨取代,以達到長期穩定的目的。目的:綜述現有不同類型支架材料的降解及其與新骨形成的關繫。方法:由第一作者從PubMed數據庫及CNKI數據庫中,以“tissue engineering bone,composite scaffold, scaffold degradation;組織工程骨,支架材料,生物降解”為主題詞檢索1996年1月至2013年12月間髮錶的文獻,選擇與支架材料降解及其與新骨形成關繫的相關文獻。結果與結論:目前已有多種有機、無機及有機-無機複閤材料作為支架材料,近年來重點是對無機材料及有機-無機材料複閤物開展研究。體內外實驗結果錶明,各類材料具備不同的特性且各有優劣。有機材料降解速率相對較慢,無機材料雖能完全降解,但機械性能不夠,對于複閤材料仍需要開展進一步的動物實驗和臨床研究。
배경:지가재료시조직공정골중요적조성부분,이상재료적생물강해속도응여신골체대생성속도일치,최종재료완전강해피신골취대,이체도장기은정적목적。목적:종술현유불동류형지가재료적강해급기여신골형성적관계。방법:유제일작자종PubMed수거고급CNKI수거고중,이“tissue engineering bone,composite scaffold, scaffold degradation;조직공정골,지가재료,생물강해”위주제사검색1996년1월지2013년12월간발표적문헌,선택여지가재료강해급기여신골형성관계적상관문헌。결과여결론:목전이유다충유궤、무궤급유궤-무궤복합재료작위지가재료,근년래중점시대무궤재료급유궤-무궤재료복합물개전연구。체내외실험결과표명,각류재료구비불동적특성차각유우렬。유궤재료강해속솔상대교만,무궤재료수능완전강해,단궤계성능불구,대우복합재료잉수요개전진일보적동물실험화림상연구。
BACKGROUND:Scaffold materials are the important part of tissue engineering bone, and the ideal biodegradation speed of the scaffold materials can be in accordance with the regeneration speed of bone formation in order to achieve a long-term stability. OBJECTIVE:To summarize the biodegradability of different types of currently available scaffold materials and its relationship with bone formation. METHODS:The PubMed and CNKI database were searched by the first author using the key words of “tissue engineering bone, composite scaffold, scaffold degradation” in English and Chinese for articles addressing biodegradability of scaffold materials and its relationship with bone formation published during January 1996 and December 2013. RESULTS AND CONCLUSION:Many scaffold materials under organic, inorganic and organic-inorganic categories have been available and the current studies focus on inorganic materials and organic-inorganic composite materials.In vivo andin vitro studies indicate the different characteristics and relative merits of these scaffold materials. Organic materials have a relatively slow degradation rate while inorganic materials can completely degrade but have an insufficient mechanical property. For organic-inorganic composite materials, further studies are needed.