CAJ | 학술논문

目的：研究与比较全脑放疗联合靶向治疗与同步放、化疗治疗非小细胞肺癌脑转移患者的临床疗效。方法：将2009年10月-2012年10月在笔者所在医院接受治疗的50例非小细胞肺癌脑转移患者作为研究对象，按照治疗方式将其分为联合治疗组35例与同步治疗组15例，对比观察两组患者的近期疗效。结果：联合治疗组整体疾病控制率为68.57%，显著高于同步治疗组的40.00%(χ2=14.587， P<0.05)；且联合治疗组的平均生存时间及1年生存率均显著高于同步治疗组，差异均有统计学意义(P<0.05)。结论：在非小细胞肺癌并脑转移患者的临床治疗中，选用全脑放疗联合靶向治疗方式效果更优，能有效改善患者的生存质量，延长其生命期限，值得推广应用。
목적：연구여비교전뇌방료연합파향치료여동보방、화료치료비소세포폐암뇌전이환자적림상료효。방법：장2009년10월-2012년10월재필자소재의원접수치료적50례비소세포폐암뇌전이환자작위연구대상，안조치료방식장기분위연합치료조35례여동보치료조15례，대비관찰량조환자적근기료효。결과：연합치료조정체질병공제솔위68.57%，현저고우동보치료조적40.00%(χ2=14.587， P<0.05)；차연합치료조적평균생존시간급1년생존솔균현저고우동보치료조，차이균유통계학의의(P<0.05)。결론：재비소세포폐암병뇌전이환자적림상치료중，선용전뇌방료연합파향치료방식효과경우，능유효개선환자적생존질량，연장기생명기한，치득추엄응용。
Objective:To study the effect of whole brain radiotherapy combined with targeted therapy and concurrent radiotherapy chemotherapy in the treatment of non-small cell lung cancer with brain metastasis.Method:50 non-small cell lung cancer with brain metastases patients who were treated in our hospital from October 2009 to October 2012 were selected as the research objects,according to the treatment methods,they were divided into the combined treatment group(n=35) and the resynchronization therapy group(n=15),the short-term effects of two groups were compared.Result:The overall disease control rate of the combined treatment group was 68.57%,was significantly higher than 40.00% of the resynchronization therapy group (χ2=14.587,P<0.05).The average survival time of the combined group and 1-year survival rate were significantly higher than those of the resynchronization therapy group,the differences were statistically significant(P<0.05).Conclusion:The clinical therapy of non-small cell lung cancer with brain metastasis, whole brain radiotherapy combined with targeted therapy effect is better,can effectively improve the quality of life of patients and prolong its life span,it is worthy of popularization and application.