CAJ | 학술논문

伴随疾病的进展,机体的代谢标志物随之发生变化,因此,代谢标志物的检测成为疾病早期诊断、治疗以及预后评价的关键.但是,代谢物质的检测,尤其是对大量代谢物质同时检测一直是检验医学难以攻克的难点.代谢组学的出现为检验医学的发展提供了新的契机,尤其是核磁共振波谱技术的新进展和应用,其具有可以在不破坏样本的基础上对大量低丰度的代谢产物进行定量检测的特点和优势.将核磁共振波谱技术与其他方法整合用于标志物的检测,将会有力提高检验医学对于疾病的辅助诊断能力.
반수질병적진전,궤체적대사표지물수지발생변화,인차,대사표지물적검측성위질병조기진단、치료이급예후평개적관건.단시,대사물질적검측,우기시대대량대사물질동시검측일직시검험의학난이공극적난점.대사조학적출현위검험의학적발전제공료신적계궤,우기시핵자공진파보기술적신진전화응용,기구유가이재불파배양본적기출상대대량저봉도적대사산물진행정량검측적특점화우세.장핵자공진파보기술여기타방법정합용우표지물적검측,장회유력제고검험의학대우질병적보조진단능력.
Molecular biomarkers could change associated with disease processes.So,the detection of metabolic markers becomes the key to early diagnosis,treatment and prognosis evaluation disease.But the detection of abundant metabolites in body becomes a crux of laboratory medicine at the same time.The recent advances in nuclear magnetic resonance (NMR) spectroscopy reveal the unequivocal value of NMR in metabolomics platforms.NMR spectroscopy has inherently distinct capabilities to identify and quantitatively measure a large amount of low concentration metabolites in a non-destructive manner.The implementation of NMR technology into a multidisciplinary approach to biomarker identification will improve the auxiliary diagnostic ability of laboratory medicine for the disease.