中国药物警戒
中國藥物警戒
중국약물경계
CHINESE JOURNAL OF PHARMACOVIGILANCE
2015年
3期
169-171
,共3页
碘普罗胺注射液%不良反应%分析
碘普囉胺註射液%不良反應%分析
전보라알주사액%불량반응%분석
iopromide injection%adverse drug reactions%analysis
目的：探讨碘普罗胺注射液致药品不良反应的临床特点及发生规律，为降低临床用药风险提供参考。方法对1994年1月～2013年12月中国期刊全文数据库文献进行检索，对其中涉及碘普罗胺注射液致不良反应病例报告进行统计与分析。结果碘普罗胺所致不良反应男性和女性比例相当，年龄分布以40～59岁组最多，发生在1 h 内占87.72%，临床表现多样、过敏性休克最多、最为严重，死亡3例。结论为确保用药安全，用药前后应注意观察，对严重的不良反应应做到早识别、早干预，应严格遵循 SFDA 建议。
目的：探討碘普囉胺註射液緻藥品不良反應的臨床特點及髮生規律，為降低臨床用藥風險提供參攷。方法對1994年1月～2013年12月中國期刊全文數據庫文獻進行檢索，對其中涉及碘普囉胺註射液緻不良反應病例報告進行統計與分析。結果碘普囉胺所緻不良反應男性和女性比例相噹，年齡分佈以40～59歲組最多，髮生在1 h 內佔87.72%，臨床錶現多樣、過敏性休剋最多、最為嚴重，死亡3例。結論為確保用藥安全，用藥前後應註意觀察，對嚴重的不良反應應做到早識彆、早榦預，應嚴格遵循 SFDA 建議。
목적：탐토전보라알주사액치약품불량반응적림상특점급발생규률，위강저림상용약풍험제공삼고。방법대1994년1월～2013년12월중국기간전문수거고문헌진행검색，대기중섭급전보라알주사액치불량반응병례보고진행통계여분석。결과전보라알소치불량반응남성화녀성비례상당，년령분포이40～59세조최다，발생재1 h 내점87.72%，림상표현다양、과민성휴극최다、최위엄중，사망3례。결론위학보용약안전，용약전후응주의관찰，대엄중적불량반응응주도조식별、조간예，응엄격준순 SFDA 건의。
Objective To study clinic features and regularity of Adverse Drug Reaction(ADR) induced by iopromide injection, so as to provide a reference to reduce the risk of its use. Methods 57 ADR cases of iopromide injection are collected and analyzed statistically from CNKI articles from Jan. 1994 to Dec. 2013. Results In 57 patients, the ratio between male and female was 1:1. The ADR was mainly from the 40~59 age group. 87.72% of ADR induced by iopromide injection occurred in 1 hour. The clinical manifestations varied broadly, in which anaphylactic shock showed the highest incidence and the severest drug adverse reaction. Three patients eventually died of severe anaphylactic reaction. Conclusion In order to ensure the safe drug use, it is necessary to carefully monitor the occurrence of anaphylactic reaction, early recognition and intervention is also critical. Clinical use of iopromide injection should follow the SFDA recommendations strictly.
