CAJ | 학술논문

背景电压依赖性阴离子通道(voltage-dependent anion channel,VDAC)形成了线粒体和胞质的分界,在代谢中有重要作用.越来越多的人研究VDAC在细胞死亡中的作用,但结果仍有争议. 目的综述VDAC在线粒体通透性调节和细胞死亡中的作用. 内容讨论支持和反对VDAC参与线粒体膜通透性转换(mitochondrial permeability transition,MPT)的证据,将VDAC参与线粒体外膜并释放细胞色素C(cytochrome C,Cyt C)的解释可分成3种模型. 趋向促进对VDAC在细胞死亡中作用的了解,对其通透性的调节有新的认识.
배경 전압의뢰성음리자통도(voltage-dependent anion channel,VDAC)형성료선립체화포질적분계,재대사중유중요작용.월래월다적인연구VDAC재세포사망중적작용,단결과잉유쟁의. 목적 종술VDAC재선립체통투성조절화세포사망중적작용. 내용 토론지지화반대VDAC삼여선립체막통투성전환(mitochondrial permeability transition,MPT)적증거,장VDAC삼여선립체외막병석방세포색소C(cytochrome C,Cyt C)적해석가분성3충모형. 추향 촉진대VDAC재세포사망중작용적료해,대기통투성적조절유신적인식.
Background Voltage-dependent anion channel (VDAC) forms the interface between mitochondria and the cytosol,and plays an important role in metabolism.Research on VDAC's role in cell death is a rapidly growing field,unfortunately with much contradictory results.Objective To review the role of VDAC in regulation of mitochondrial permeability and cell death.Content To begin,we will discuss the evidence for and against VDAC's involvement in mitochondrial permeability transition (MPT),and then existing evidence of how VDAC is involved in outer membrane permeability and release of cytochrome C (Cyt C) can be grouped into roughly three models.Trend In addition to understand the role of VDAC in cell death and gain new knowledge about regulators of VDAC permeability.