CAJ | 학술논문

采用原位细胞电化学法研究了紫杉醇药物作用时间和作用剂量对MCF－7细胞电化学信号的影响。结果显示，细胞电化学信号可以很好地反映紫杉醇对MCF－7细胞作用的时间，剂量依赖性。将原位电化学法与MTT法检测紫杉醇对MCF－7细胞活性的影响结果进行比较，得到一致的趋势，表明原位细胞电化学法可以发展为一种有效的体外抗癌药物筛选新方法。
채용원위세포전화학법연구료자삼순약물작용시간화작용제량대MCF－7세포전화학신호적영향。결과현시，세포전화학신호가이흔호지반영자삼순대MCF－7세포작용적시간，제량의뢰성。장원위전화학법여MTT법검측자삼순대MCF－7세포활성적영향결과진행비교，득도일치적추세，표명원위세포전화학법가이발전위일충유효적체외항암약물사선신방법。
The effect of action time and dose of paclitaxel on electrochemical signals of MCF -7 cell was studied by in situ cell electrochemical method .The result showed that the electrochemical signals can well reflect the dependency of action time and dose of drug with MCF -7 cell.And in situ cell electrochemical and MTT method for cell activity detection was compared and the result was concordant .It indicated that in situ cell elec-trochemical method could become an effective method for anticancer drug screening .