贵阳医学院学报
貴暘醫學院學報
귀양의학원학보
JOURNAL OF GUIYANG MEDICAL COLLEGE
2015年
3期
291-293
,共3页
王璐%付蓉%赵晶%李昌%彭忠勇
王璐%付蓉%趙晶%李昌%彭忠勇
왕로%부용%조정%리창%팽충용
痴呆,血管性%综合征%盐酸多奈哌齐%尼莫地平%简明精神病状态评定量表
癡呆,血管性%綜閤徵%鹽痠多奈哌齊%尼莫地平%簡明精神病狀態評定量錶
치태,혈관성%종합정%염산다내고제%니막지평%간명정신병상태평정량표
dementia,vascular%syndrome%donepezil%nimodipine%mini mental state examination
目的:观察盐酸多奈哌齐联合尼莫地平治疗血管性痴呆的临床疗效。方法:血管性痴呆患者60例,随机分为观察组和对照组,对照组服用盐酸多奈哌齐(5 mg/d),每晚临睡前口服;观察组在对照组的用药基础上联用尼莫地平片30 mg,3次/d ,疗程8周;采用简易精神状态检查表( mmSE)、临床痴呆量表( CDR)及日常生活自理量表( ADL)于治疗前、治疗4周及治疗8周时对2组患者进行评分,评价疗效,同时观察两组不良反应。结果:观察组治疗后 mmSE、CDR及 ADL评分均较治疗前明显改善,差异有统计学意义( P <0.01,P <0.05,P<0.01);对照组治疗后mmSE、CDR评分较治疗前明显改善,差异有统计学意义( P<0.01,P<0.05), ADL分数虽较治疗前减少,但差异无统计学意义( P>0.05),两组均无严重不良反应。结论:盐酸多奈哌齐联合尼莫地平治疗血管性痴呆的疗效优于单独使用盐酸多奈哌齐。
目的:觀察鹽痠多奈哌齊聯閤尼莫地平治療血管性癡呆的臨床療效。方法:血管性癡呆患者60例,隨機分為觀察組和對照組,對照組服用鹽痠多奈哌齊(5 mg/d),每晚臨睡前口服;觀察組在對照組的用藥基礎上聯用尼莫地平片30 mg,3次/d ,療程8週;採用簡易精神狀態檢查錶( mmSE)、臨床癡呆量錶( CDR)及日常生活自理量錶( ADL)于治療前、治療4週及治療8週時對2組患者進行評分,評價療效,同時觀察兩組不良反應。結果:觀察組治療後 mmSE、CDR及 ADL評分均較治療前明顯改善,差異有統計學意義( P <0.01,P <0.05,P<0.01);對照組治療後mmSE、CDR評分較治療前明顯改善,差異有統計學意義( P<0.01,P<0.05), ADL分數雖較治療前減少,但差異無統計學意義( P>0.05),兩組均無嚴重不良反應。結論:鹽痠多奈哌齊聯閤尼莫地平治療血管性癡呆的療效優于單獨使用鹽痠多奈哌齊。
목적:관찰염산다내고제연합니막지평치료혈관성치태적림상료효。방법:혈관성치태환자60례,수궤분위관찰조화대조조,대조조복용염산다내고제(5 mg/d),매만림수전구복;관찰조재대조조적용약기출상련용니막지평편30 mg,3차/d ,료정8주;채용간역정신상태검사표( mmSE)、림상치태량표( CDR)급일상생활자리량표( ADL)우치료전、치료4주급치료8주시대2조환자진행평분,평개료효,동시관찰량조불량반응。결과:관찰조치료후 mmSE、CDR급 ADL평분균교치료전명현개선,차이유통계학의의( P <0.01,P <0.05,P<0.01);대조조치료후mmSE、CDR평분교치료전명현개선,차이유통계학의의( P<0.01,P<0.05), ADL분수수교치료전감소,단차이무통계학의의( P>0.05),량조균무엄중불량반응。결론:염산다내고제연합니막지평치료혈관성치태적료효우우단독사용염산다내고제。
Objective:To observe the clinical curative effect of donepezil combined with nimodipine in the treatment of vascular dementia. Methods:Sixty patients with vascular dementia were randomly divided into observation group( donepezil combined with nimodipine)and control group( single done-pezil group),the patients in control group were given oral donepezil(5mg/d)every night before going to sleep;based on the treatment of control group,the patients in observation group was treated with ni-modipine tablets 30 mg tid for 8 weeks,all the subjects were followed up every 4 weeks. mini mental state examination( mmSE),the clinical dementia rating scale( CDR)and daily living scale( ADL) were used to evaluate the curative effect. Results:mmSE,CDR and ADL scores in the observation group were significantly improved after treatment(P <0. 01,P <0. 05,P <0. 01). mmSE,CDR scores in the control group were significantly improved after treatment( P< 0 . 01 ,P<0 . 05 ),ADL score was decreased after treatment in control group,but the difference was not statistically significant (P>0. 05). There was no serious adverse reaction in both the two groups. Conclusions:The thera-peutic effect of donepezil combined with nimodipine in the treatment of vascular dementia is better than single use of donepezil hydrochloride.