CAJ | 학술논문

目的：观察Ⅰ~Ⅱ期乳腺癌保乳手术后辅助放化疗的效果。方法：Ⅰ~Ⅱ期乳腺癌患者65例，行乳腺癌保留乳房手术治疗，术后采用蒽环类或紫杉类药物为主的联合化疗，辅助放疗采用调强放疗技术行全乳房照射；观察患者辅助放化疗的毒副反应、乳房美容效果、局部复发、远处转移及生存情况。结果：随访12~78个月，4年生存率为100%，3例发生远处转移（4.6%），放疗主要急性毒副反应为Ⅰ~Ⅱ度皮肤反应（87.7%）及Ⅰ度骨髓抑制（46.1%），化疗主要毒副反应表现为Ⅰ~Ⅱ度骨髓抑制（86.4%）、Ⅰ~Ⅱ度消化道反应（88.1%）及Ⅱ~Ⅲ度脱发（74.6%）；乳房美容效果优良57例（88%）；不满意者8例（12%）。结论：Ⅰ~Ⅱ期乳腺癌患者行保乳手术后辅助放化疗疗效肯定，毒副反应可以耐受，治疗结束后乳房满意度良好。
목적：관찰Ⅰ~Ⅱ기유선암보유수술후보조방화료적효과。방법：Ⅰ~Ⅱ기유선암환자65례，행유선암보류유방수술치료，술후채용은배류혹자삼류약물위주적연합화료，보조방료채용조강방료기술행전유방조사；관찰환자보조방화료적독부반응、유방미용효과、국부복발、원처전이급생존정황。결과：수방12~78개월，4년생존솔위100%，3례발생원처전이（4.6%），방료주요급성독부반응위Ⅰ~Ⅱ도피부반응（87.7%）급Ⅰ도골수억제（46.1%），화료주요독부반응표현위Ⅰ~Ⅱ도골수억제（86.4%）、Ⅰ~Ⅱ도소화도반응（88.1%）급Ⅱ~Ⅲ도탈발（74.6%）；유방미용효과우량57례（88%）；불만의자8례（12%）。결론：Ⅰ~Ⅱ기유선암환자행보유수술후보조방화료료효긍정，독부반응가이내수，치료결속후유방만의도량호。
Objective:To observe the effect of adjuvant chemoradiation in breast cancer with stageⅠ~Ⅱ after breast conservative surgery( BCS ). Methods:Sixty-five patients of breast cancer(Ⅰ~Ⅱ)received treatment of breast conservative surgery and the combination chemotherapy of anthracy-cline or taxane were adopted in postoperative therapy. The intensity modulated radiotherapy( ImRT) was used for the whole breast irradiation in adjuvant radiotherapy. The toxicity and side reactions, breast cosmetic result,local recurrence,distant metastasis and overall survival situation were ob-served. Results:After follow-up of 12 to 78 months,it was observed that 4-year survival rate was 100%,of which 3 cases appeared distant metastasis(3/65,4. 6%). In radiotherapy the major acute toxicity and side reactions wereⅠ~Ⅱdegree skin reactions(87. 7%)andⅠdegree myelo suppres-sion(46. 1%). The main side effects of chemotherapy wereⅠ~II degree myelo suppression(86. 4%),Ⅰ~Ⅱdegree gastrointestinal reactions(88. 1%)andⅡ~ Ⅲdegree hair loss(74. 6%). In breast cos-metic result,57 cases were excellent,accounting for 88%. 8 cases were unsatisfactory,accounting for 12%. Conclusions:The curative effect is certain forⅠ~Ⅱstage breast cancer treated with BCS plus adjuvant chemoradiation. The toxic and side effects are mild and the breast cosmetic result is satisfac-tory.