CAJ | 학술논문

目的：评价脑脊液流式细胞术（ CSF-FCm）在非霍奇金淋巴瘤（ NHL）中枢神经系统（ CNS）受侵的诊断和预后的价值。方法：18例NHL初治患者，脑脊液（ CSF）采用CSF-FCm和脑脊液细胞学（ CSF-C）方法检测，比较两种方法检测中枢神经系统（ CNS）受累的阳性率，同时观察患者性别、年龄、临床分期、B症状、乳酸脱氢酶（ LDH）、国际预后指数（ IPI）评分、体能状态PS评分等相关临床因素的关系。结果：CSF-FCm检测NHL患者CNS受侵的诊断阳性率高于 CSF-C，差异有统计学意义（ P =0.045）；单因素分析结果显示 CSF-FCm 在检测NHLCNS受累时免疫表型阳性与年龄、B症状及LDH有关（ P=0.039、0.001及0.009）。结论：NHL累及CNS时CSF-FCm免疫表型检测优于传统细胞学检查。
목적：평개뇌척액류식세포술（ CSF-FCm）재비곽기금림파류（ NHL）중추신경계통（ CNS）수침적진단화예후적개치。방법：18례NHL초치환자，뇌척액（ CSF）채용CSF-FCm화뇌척액세포학（ CSF-C）방법검측，비교량충방법검측중추신경계통（ CNS）수루적양성솔，동시관찰환자성별、년령、림상분기、B증상、유산탈경매（ LDH）、국제예후지수（ IPI）평분、체능상태PS평분등상관림상인소적관계。결과：CSF-FCm검측NHL환자CNS수침적진단양성솔고우 CSF-C，차이유통계학의의（ P =0.045）；단인소분석결과현시 CSF-FCm 재검측NHLCNS수루시면역표형양성여년령、B증상급LDH유관（ P=0.039、0.001급0.009）。결론：NHL루급CNS시CSF-FCm면역표형검측우우전통세포학검사。
Objective:To evaluate the value of diagnosis and prognosis with cerebrospinal fluid flow cytometry( CSF -FCm)in non-hodgkin′s lymphoma( NHL)of the central nervous system( CNS)in-vaded. Methods:CSF-FCm and CSF cytology were employed to detect cerebrospinal fluid( CSF)of 18 NHL patients of initial treatment,positive rate of central nervous system( CNS)involvement detec-ted by the two methods were compared,at the same time,the correlation among clinical factors such as patients′gender,age,clinical stage,B symptoms,lactate dehydrogenase( LDH),international prog-nostic index( IPI)score,PS score of physical state was observed. Results:The diagnostic positive rate of CSF-FCm in detecting NHL patients with CNS invaded was higher than that of CSF-C,the difference was statistically significant( P=0 . 045 ). Single factor analysis showed that immune pheno-types of NHL which CNS invaded detected by CSF-FCm was correlated to age,B symptoms and LDH ( P=0 . 039 ,0 . 001 and 0 . 009 ). Conclusions:CSF-FCm immune phenotypic detection is superior to the conventional cytology when CNS involvement in NHL.