CAJ | 학술논문

背景认知解耦联是指在大脑中特定的认知活动合成受损,是意识消失的一种模式.认知解耦联也许是不同麻醉药物作用的共同机制. 目的综述认知解耦联的基本概念及其与全身麻醉意识消失的关系. 内容以全身麻醉意识消失为中心,结合神经影像学、神经生理学证据,表明认知解耦联是麻醉诱导意识消失的直接原因.认知解耦联与睡眠和其他原因的意识障碍有一定的相关性,可能是全身麻醉和其他无意识状态的共同机制. 趋向认知解耦联为全身麻醉意识消失机制的研究提供了新的方向,要求将电生理技术和影像学技术结合用于全身麻醉机制的研究.
배경 인지해우련시지재대뇌중특정적인지활동합성수손,시의식소실적일충모식.인지해우련야허시불동마취약물작용적공동궤제. 목적 종술인지해우련적기본개념급기여전신마취의식소실적관계. 내용 이전신마취의식소실위중심,결합신경영상학、신경생이학증거,표명인지해우련시마취유도의식소실적직접원인.인지해우련여수면화기타원인적의식장애유일정적상관성,가능시전신마취화기타무의식상태적공동궤제. 추향 인지해우련위전신마취의식소실궤제적연구제공료신적방향,요구장전생리기술화영상학기술결합용우전신마취궤제적연구.
Background Cognitive unbinding means the impaired synthesis of specialized cognitive processing in the brain,which is a kind of paradigm of unconsciousness.Cognitive unbinding may be the common mechanism of different anesthetics.Objective To reviewe the basic concept of cognitive unbinding and its relationship with general anesthetic-induced unconsciousness.Content Taking general anesthesia-induced unconsciousness as a central state,this article draws the evidence from neuroimaging and neurophysiology data,which supports the proposition that cognitive unbinding is a direct cause of general anesthetic-induced unconsciousness.The relevance of cognitive unbinding to sleep and other disorders of consciousness is also possible.Cognitive unbinding may be a common mechanism for general anesthesia and other unconscious states.Trend Cognitive unbinding provides a new direction for the study of general anesthetic-induced unconsciousness.The study about the mechanism of general anesthesia needs the combination of electrophysiological and imaging technologies.