CAJ | 학술논문

肥胖（ obesity）是阿尔茨海默病（ Alzheimer’s disease，AD）的独立危险因子，这不仅与胰岛素抵抗有关，可能还与机体慢性炎症联系密切。肥胖在阿尔茨海默症的发病机制中扮演重要角色，它能诱发胰岛素抵抗产生β－淀粉样蛋白沉积和Tau蛋白过度磷酸化导致AD；肥胖时脂肪组织所产生的肿瘤坏死因子、白介素－1、白介素－6等炎症因子，互相影响，共同导致阿尔茨海默症。本文对肥胖产生的胰岛素抵抗和某些炎症因子与阿尔茨海默病的发病机制的研究进行综述，就肥胖因素为临床阿尔茨海默病的预防和治疗提供参考。
비반（ obesity）시아이자해묵병（ Alzheimer’s disease，AD）적독립위험인자，저불부여이도소저항유관，가능환여궤체만성염증련계밀절。비반재아이자해묵증적발병궤제중분연중요각색，타능유발이도소저항산생β－정분양단백침적화Tau단백과도린산화도치AD；비반시지방조직소산생적종류배사인자、백개소－1、백개소－6등염증인자，호상영향，공동도치아이자해묵증。본문대비반산생적이도소저항화모사염증인자여아이자해묵병적발병궤제적연구진행종술，취비반인소위림상아이자해묵병적예방화치료제공삼고。
Objectives Is the Independent risk factor for Alzheimer’s disease, It is not only related to insulin resistance, but al-so closely related to the body’s chronic inflammation.Obesity plays an important role in the pathogenesis of in Alzheimer’s disease.It can induce insulin resistance produce beta-amyloid deposition and excessive Tau protein phosphorylation leading to AD, adipose tis-sue Produced some inflammation factors, such as tumor necrosis factor,interleukin-1, and interleukin-6 factors in obesity, and in-fluence each other, common cause Alzheimer’s disease.In this paper, the obesity produce insulin resistance and certain inflammatory factors which further cause the pathogenesis of Alzheimer’s disease research are reviewed.In obese factor for clinical prevention and treatment of Alzheimer’s disease to provide the reference.